Lysyl Oxidase 473 G>A Polymorphism and Breast Cancer Susceptibility in Chinese Han Population
Lysyl Oxidase 473 G>A Polymorphism and Breast Cancer Susceptibility in Chinese Han Population
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DOI：
10.1089/dna.2010.1098
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发表时间：
2011-02-01
影响因子：
3.1
通讯作者：
Huang, Tao
中科院分区：
文献类型：
--
作者：
Ren, Jinghua;Wu, Xiaoling;Huang, Tao
赖氨酰氧化酶（LOX）是一种细胞外酶，对胶原蛋白和弹性蛋白的交联至关重要。LOX基因也被证明抑制Ras癌基因信号传导的转化活性。最近，LOX G473 A（rs 1800449）的单核苷酸多态性（SNP）已被证明与非洲裔美国妇女乳腺癌风险增加相关。本研究以医院为基础，采用病例对照研究方法，探讨LOX基因多态性与中国汉族人群乳腺癌易感性的关系。总共招募了238名女性乳腺癌患者和234名年龄匹配的健康对照者进行基因分型。我们发现乳腺癌和对照组之间LOX G473 A基因型的频率有显著差异。GA基因型个体患乳腺癌的风险是GG基因型个体的2.79倍（95%可信区间= 1.87-4.16）（p < 0.001）。进一步的统计学分析显示，该多态性是一个独立的参数，其他变量显着相关的乳腺癌，即，年龄，绝经状态，雌激素暴露间隔，雌激素受体的表达状态，孕激素受体。这些结果表明，LOX 473 GA基因型与中国女性乳腺癌的风险增加独立相关。
Lysyl oxidase (LOX) is an extracellular enzyme critical for the cross-linking of collagens and elastin. The LOX gene has also been shown to inhibit the transforming activity of Ras oncogene signaling. Recently, a single-nucleotide polymorphism (SNP) of LOX G473A (rs1800449) has been demonstrated to be associated with increased risk of breast cancer in African American women. In this hospital-based case-control study, the association of LOX polymorphism with breast cancer susceptibility in Chinese Han population was investigated. In total, 238 female patients with breast cancer and 234 age-matched healthy controls recruited were genotyped. We found a significant difference in the frequency of the LOX G473A genotype between the breast cancer and control groups. Individuals with GA genotype showed a 2.79-fold (95% confidence interval = 1.87-4.16) increased risk of breast cancer compared with subjects carrying GG genotype (p < 0.001). Further statistical analysis revealed that this polymorphism was an independent parameter with regard to other variables that are significantly associated with breast cancer, that is, age, menopausal status, estrogen exposure interval, expression status of estrogen receptor, and progesterone receptor. These findings suggest that the LOX 473 GA genotype is independently associated with increased risk of breast cancer in Chinese female population.