Activated protein C resistance in pediatric inflammatory bowel disease.
Activated protein C resistance in pediatric inflammatory bowel disease.
复制标题
小儿炎症性肠病中激活的蛋白 C 抵抗力。
DOI：
10.1097/00005176-199802000-00009
复制
发表时间：
1998
影响因子：
2.9
通讯作者：
Gabriel Dinari
中科院分区：
文献类型：
--
作者：
Arie Levine;Judith Lahav;I. Zahavi;Arie Raz;Gabriel Dinari
背景
有证据表明炎症性肠病（IBD）中存在高凝状态，并且已在克罗恩病患者的肠道中发现小血管血栓形成，表明血栓形成是可能的病因。活化蛋白C（APC）抵抗是导致血栓形成的最常见遗传性疾病，占特发性静脉血栓形成发作的30%至40%。
方法
采用APC耐药筛查方法，研究了23例IBD患者（17例克罗恩病，6例溃疡性结肠炎）和11例复发性腹痛或乳糜泻的对照受试者中APC耐药的患病率。
结果
一名克罗恩病患者的筛查结果为阳性，两名患者（一名克罗恩病患者，一名溃疡性结肠炎患者）的结果为临界值，所有对照受试者的结果均正常。1例克罗恩病患者有血栓栓塞事件史，但筛查结果正常。
结论
活化蛋白C抵抗在炎症性肠病高凝状态的病因学中似乎并不起主要作用。
BACKGROUND
There is evidence for a hypercoagulable state in inflammatory bowel disease (IBD), and small vessel thrombosis has been identified in the bowel of patients with Crohn's disease, suggesting thrombosis as a possible etiologic factor. Activated protein C (APC) resistance is the most common inherited disorder leading to thrombosis and accounts for 30% to 40% of episodes of idiopathic venous thrombosis.
METHODS
The prevalence of APC resistance was studied in 23 patients with IBD (17 with Crohn's disease, 6 with ulcerative colitis) and in 11 control subjects with recurrent abdominal pain or celiac disease, using an APC resistance screening method.
RESULTS
One patient with Crohn's disease had a positive screen result, two patients (one with Crohn's, one with ulcerative colitis) had borderline results, and results in all of the control subjects were normal. One patient with Crohn's disease had a history of a thromboembolic event but had a normal screen result.
CONCLUSIONS
Activated protein C resistance does not seem to play a major role in the etiology of the hypercoagulable state in inflammatory bowel disease.