Improved antimicrobial peptides based on acyl-lysine oligomers
Improved antimicrobial peptides based on acyl-lysine oligomers
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DOI：
10.1038/nbt1309
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发表时间：
2007-06-01
影响因子：
46.9
通讯作者：
Mor, Amram
中科院分区：
文献类型：
--
作者：
Radzishevsky, Inna S.;Rotem, Shahar;Mor, Amram
我们描述了在小鼠中显示快速、非溶血、广谱杀菌特性并且不诱导出现耐药性的肽模拟物寡聚体。低聚物含有酰基链，这阻止了稳定二级结构的形成。这种设计在体内功效和安全性方面优于常规抗微生物肽，并且可以为肽抗生素的开发提供方便的平台。
We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.