Structural connectivity in a single case of progressive prosopagnosia: The role of the right inferior longitudinal fasciculus
Structural connectivity in a single case of progressive prosopagnosia: The role of the right inferior longitudinal fasciculus
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DOI：
10.1016/j.cortex.2012.09.010
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发表时间：
2014-07-01
期刊：
影响因子：
3.6
通讯作者：
Trojano, Luigi
中科院分区：
文献类型：
--
作者：
Grossi, Dario;Soricelli, Andrea;Trojano, Luigi
进行性面孔失认症（PP）是一种临床综合征，其特征是进行性和选择性地不能识别和识别熟悉的人的面孔。在这里，我们报告一个病人（G.S.）与PP，主要涉及到一个突出的缺陷，在识别熟悉的面孔，没有语义（跨模态）的损害。一项深入的评估表明，他的缺陷延伸到其他类别的对象，无论是生活和非生活。一个后续的神经心理学评估没有发现实质性的变化后，约1年。结构MRI显示主要的右颞叶萎缩，扩散张量成像，以阐明结构连接的下纵束（ILF）和下额枕束（IFOF），两个主要的束，通过核心梭状区的前颞叶和额叶皮质，分别。右侧ILF在G.S.中显著减少，而左ILF和IFOF明显保留。这些数据是赞成的神经回路subserved右ILF在PP的发病机制中的关键作用。(C)2012爱思唯尔有限公司保留所有权利。
Progressive prosopagnosia (PP) is a clinical syndrome characterized by a progressive and selective inability to recognize and identify faces of familiar people. Here we report a patient (G.S.) with PP, mainly related to a prominent deficit in recognition of familiar faces, without a semantic (cross-modal) impairment. An in-depth evaluation showed that his deficit extended to other classes of objects, both living and non-living. A follow-up neuropsychological assessment did not reveal substantial changes after about 1 year. Structural MRI showed predominant right temporal lobe atrophy.Diffusion tensor imaging was performed to elucidate structural connectivity of the inferior longitudinal fasciculus (ILF) and the inferior fronto-occipital fasciculus (IFOF), the two major tracts that project through the core fusiform region to the anterior temporal and frontal cortices, respectively. Right ILF was markedly reduced in G.S., while left ILF and IFOFs were apparently preserved. These data are in favour of a crucial role of the neural circuit subserved by right ILF in the pathogenesis of PP. (C) 2012 Elsevier Ltd. All rights reserved.