BEHAVIORAL AND ENDOCRINE RESPONSES OF FEMALE MICE TO SYNTHETIC ANALOGS OF VOLATILE COMPOUNDS IN MALE URINE
BEHAVIORAL AND ENDOCRINE RESPONSES OF FEMALE MICE TO SYNTHETIC ANALOGS OF VOLATILE COMPOUNDS IN MALE URINE
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DOI：
10.1016/s0003-3472(85)80170-6
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发表时间：
1985-01-01
期刊：
影响因子：
2.5
通讯作者：
NOVOTNY, M
中科院分区：
文献类型：
--
作者：
JEMIOLO, B;ALBERTS, J;NOVOTNY, M
完整的成年雄性小鼠的尿液比去势的雄性小鼠的尿液更能引起雌性小鼠的调查性嗅觉。当两种雄激素依赖的尿液化合物2-仲丁基二氢噻唑或脱氢-外源性灯盏花素加入去势尿中时，其相对吸引力保持不变。然而，当这两种化合物被添加到去势尿液中时，它的活性会增强，而且去势后的尿液对女性的吸引力与完整的男性尿液一样。雌鼠每天接触重组的“正常”尿液3分钟，表现出更频繁的发情周期。这两种合成化合物在去势尿液中是协同作用的，产生一种嗅觉信息，在行为和生理上模仿正常生物信号的活动。
The urine of intact, adult male mice elicits more investigatory sniffing from female mice than does the urine of castrated males. When either of two androgen-dependent urinary compounds, 2-sec-butyldihydrothiazole or dehydro-exo-brevicomin are added to castrate urine, its relative attractiveness remains the same. When both compounds are added to castrate urine, however, its activity is enhanced and the castrate urine becomes as attractive to females as whole, intact male urine. Females exposed to the reconstituted ''normal'' urine for 3 min per day, displayed more frequent estrous cycles. The two synthetic compounds are synergistic in the context of castrate urine, producing an olfactory message that behaviorally and physiologically mimics the activity of the normal biological signal.