Serum and CSF neurofilament light chain levels in antibody-mediated encephalitis
Serum and CSF neurofilament light chain levels in antibody-mediated encephalitis
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DOI：
10.1007/s00415-019-09306-z
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发表时间：
2019-07-01
影响因子：
6
通讯作者：
Ferrari, Sergio
中科院分区：
文献类型：
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作者：
Mariotto, Sara;Gajofatto, Alberto;Ferrari, Sergio
循环和脑脊液（CSF）神经丝轻链（NfL）水平代表了不同神经炎症条件下疾病活动和轴突损伤的可靠指标。最近，已在活动性自身免疫性脑炎中检测到高CSF NfL水平，而不是临床改善后的显著较低水平。本研究的目的是评估自身免疫性脑炎患者的血清和CSF NfL浓度，并分析NfL水平与临床、MRI和CSF数据之间的相关性。我们回顾性纳入了25例与神经元细胞表面抗原自身抗体相关的神经系统综合征患者，并收集了临床、MRI、CSF和随访数据。使用超灵敏的方法（Simoa，Quanterix），我们测量了所有患者的血清和CSF样本以及25名健康对照血清中的NfL水平。所有病例的血清NfL水平均高于对照组（中位数6.9pg/ml，范围2.7-12.8; p <0.05），其中包括20例具有炎症性MRI/CSF特征的患者和5例非炎症性病例（中位数16.9pg/ml，范围4.5-90）。
Circulating and cerebrospinal fluid (CSF) neurofilament light chain (NfL) levels represent a reliable indicator of disease activity and axonal damage in different neuroinflammatory conditions. Recently, high CSF NfL levels have been detected in active autoimmune encephalitis, as opposed to significant lower levels after clinical improvement. The aim of the present study was to evaluate serum and CSF NfL concentration in patients with autoimmune encephalitis and to analyse the association between NfL levels and clinical, MRI, and CSF data. We retrospectively included 25 patients with neurological syndromes associated with autoantibodies to neuronal cell surface antigens and we collected clinical, MRI, CSF, and follow-up data. Using an ultrasensitive method (Simoa, Quanterix), we measured NfL levels in serum and CSF samples of all patients and in 25 sera of healthy controls. Serum NfL levels were higher in all cases, including 20 patients with inflammatory MRI/CSF features and 5 non-inflammatory cases (median 16.9pg/ml, range 4.5-90) than in controls (median 6.9pg/ml, range 2.7-12.8; p