Laser optoacoustic imaging system for detection of breast cancer
Laser optoacoustic imaging system for detection of breast cancer
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DOI：
10.1117/1.3086616
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发表时间：
2009-03-01
影响因子：
3.5
通讯作者：
Oraevsky, Alexander A.
中科院分区：
文献类型：
--
作者：
Ermilov, Sergey A.;Khamapirad, Tuenchit;Oraevsky, Alexander A.
我们设计、制造并测试了用于乳腺癌检测的激光光声成像系统（LOIS - 64），该系统通过利用脉冲光照明以及对产生的光声（OA）信号进行超宽带超声检测，将光学和声学成像技术融合在一种模式中。该系统设计用于以头足位或内外侧位对单个乳腺切片进行成像，采用由64个超宽带声学换能器组成的弧形阵列。该系统对乳腺体模的分辨率至少为0.5毫米。单通道灵敏度为1.66毫伏/帕，据估计足以对乳腺整个成像切片中6至11毫米的肿瘤进行单脉冲成像。采用小波变换实现的信号处理显著降低了低频（LF）声学噪声，实现了对肿瘤光声信号的定位，并增强了肿瘤光声图像的对比度和边界清晰度。在对27名患者进行的初步临床研究中，LOIS - 64能够使20个在乳腺X线摄影和超声图像中疑似为恶性且经光声断层成像（OAT）程序后进行的活检所确认的病变中的18个可视化。（C）2009年美国光电仪器工程师协会。[DOI: 10.1117/1.3086616]
We designed, fabricated and tested the laser optoacoustic imaging system for breast cancer detection (LOIS-64), which fuses optical and acoustic imaging techniques in one modality by utilizing pulsed optical illumination and ultrawide-band ultrasonic detection of resulting optoacoustic (OA) signals. The system was designed to image a single breast slice in craniocaudal or mediolateral projection with an arc-shaped array of 64 ultrawide-band acoustic transducers. The system resolution on breast phantoms was at least 0.5 mm. The single-channel sensitivity of 1.66 mV/Pa was estimated to be sufficient for single-pulse imaging of 6 to 11 mm tumors through the whole imaging slice of the breast. The implemented signal processing using the wavelet transform allowed significant reduction of the low-frequency (LF) acoustic noise, allowed localization of the optoacoustic signals from tumors, and enhanced the contrast and sharpened the boundaries of the optoacoustic images of the tumors. During the preliminary clinical studies on 27 patients, the LOIS-64 was able to visualize 18 out of 20 malignant lesions suspected from mammography and ultrasound images and confirmed by the biopsy performed after the optoacoustic tomography (OAT) procedure. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3086616]