Role of cannabinoid CB2 receptors in glucose homeostasis in rats
Role of cannabinoid CB2 receptors in glucose homeostasis in rats
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DOI：
10.1016/j.ejphar.2007.02.066
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发表时间：
2007-06-22
影响因子：
5
通讯作者：
Rodriguez de Fonseca, Fernando
中科院分区：
文献类型：
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作者：
Bermudez-Silva, Francisco Javier;Sanchez-Vera, Irene;Rodriguez de Fonseca, Fernando
在这里，我们表明大麻素CB2受体的激活改善了葡萄糖负荷后的葡萄糖耐量。阻断大麻素CB2受体抵消了这种作用，导致葡萄糖耐受不良。由于大麻素CB1受体的阻断模仿大麻素CB2受体激动剂的作用，我们提出内源性大麻素系统通过大麻素CB1和CB2受体的协调作用调节葡萄糖稳态。我们还描述了大麻素CB1和CB2受体免疫反应性在大鼠胰腺β和非β细胞中的存在，将内分泌胰腺、脂肪组织和肝脏作为内源性大麻素调节葡萄糖稳态的潜在位点。(c) 2007 Elsevier B.V.版权所有
Here we show that the activation of cannabinoid CB2 receptors improved glucose tolerance after a glucose load. Blockade of cannabinoid CB2 receptors counteracted this effect, leading to glucose intolerance. Since blockade of cannabinoid CB1 receptors mimics the actions of cannabinoid CB2 receptor agonists, we propose that the endocannabinoid system modulates glucose homeostasis through the coordinated actions of cannabinoid CB1 and CB2 receptors. We also describe the presence of both cannabinoid CB1 and CB2 receptor immunoreactivity in rat pancreatic beta- and non-beta-cells, adding the endocrine pancreas to adipose tissue and the liver as potential sites for endocannabinoid regulation of glucose homeostasis. (c) 2007 Elsevier B.V. All rights reserved.