Lactobacillus gasseri OLL2809 is effective especially on the menstrual pain and dysmenorrhea in endometriosis patients: randomized, double-blind, placebo-controlled study
Lactobacillus gasseri OLL2809 is effective especially on the menstrual pain and dysmenorrhea in endometriosis patients: randomized, double-blind, placebo-controlled study
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DOI：
10.1007/s10616-010-9326-5
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发表时间：
2011-03-01
期刊：
影响因子：
2.2
通讯作者：
Kaminogawa, Shuichi
中科院分区：
文献类型：
--
作者：
Itoh, Hiroyuki;Uchida, Masayuki;Kaminogawa, Shuichi
本研究通过随机、双盲、安慰剂对照的临床研究，评价了加氏乳杆菌OLL2809对子宫内膜异位症的疗效，尤其是对疼痛的疗效，疼痛是导致生活质量下降的因素之一。66例临床诊断为子宫内膜异位症的患者入组本研究，其中62例已成功完成试验。含100 mg L.每天一次摄入gasseri OLL2809（活性片剂，n = 29）或安慰剂片剂（n = 33），持续12周。与安慰剂片剂相比，服用活性片剂可显著改善月经期疼痛强度的视觉模拟量表（VAS）和痛经的口头评定量表（VRS）。入组患者的血液检查和血液生化检查无明显变化。以上结果表明，含L. gasseri OLL2809对子宫内膜异位症有效，特别是对月经痛和痛经。此外，还发现该片剂没有不良反应。因此，建议含L. gaserri OLL2809有助于改善子宫内膜异位症患者的生活质量。
In this study, we evaluated the efficacy of Lactobacillus gasseri OLL2809 on endometriosis by the randomized, double-blind and placebo-controlled clinical study, especially against pain, which is one of the causative factors to decrease the quality of life. Sixty-six patients clinically diagnosed with endometriosis were enrolled in this study, 62 of which have successfully completed the trial. The tablets containing 100 mg of L. gasseri OLL2809 (active tablet, n = 29) or placebo tablets (n = 33) were ingested once a day for 12 weeks. Visual analog scale (VAS) of pain intensity at the menstrual period and verbal rating scale (VRS) of dysmenorrhea were significantly improved by the ingestion of the active tablets as compared with placebo tablets. There was no significant change of blood examination and biochemical examination of blood in the enrolled patients. Above results show that the tablet containing L. gasseri OLL2809 is effective on endometriosis, especially against menstrual pain and dysmenorrhea. Moreover, it was found that the tablet has no adverse effects. Therefore, it was suggested that the tablet containing L. gaserri OLL2809 contributes to improve the quality of life in the patients with endometriosis.