rsonic Acid-Presenting Super paramagnetic Iron Oxide for pH-Responsive Aggregation under Slight Acidic Conditions
rsonic Acid-Presenting Super paramagnetic Iron Oxide for pH-Responsive Aggregation under Slight Acidic Conditions
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具有酸性的超顺磁性氧化铁，可在弱酸性条件下实现 pH 响应性聚集
DOI：
10.1016/j.bmc.2011.02.027
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Y.
中科院分区：
文献类型：
--
作者：
Minehara;H.; Naka;K.; Tanaka;K.; Narita;A.; Chujo;Y.
报道了含砷酸的超顺磁性氧化铁(SPIO)的合成和表征。在水相介质中，我们使用了芳香酸作为SPIO的配体。SPIO的表面修饰是通过从十一酸到芳香酸的羧基部分的配体交换来完成的。从而得到了在水中分散良好的阿索酸SPIO。我们发现，生物显着区域的pH变化可以很好地调节呈递阿索酸的SPIO的分散状态。在中性的pH范围内，能够保持呈阿索酸的SPIO的良好分散状态。相反，在pH 6.1以下，呈阿索酸的SPIO能灵敏地形成聚集体。此外，这些分散状态可以通过狭窄区域内的pH变化进行可逆控制。
We report the synthesis and characterization of the arsonic acid-presenting superparamagnetic iron oxide (SPIO). We used arsonoacetic acid as the ligand for SPIOs in aqueous media. The surface modification of the SPIOs was accomplished via the ligand exchange from undecanoic acid to the carboxyl moiety of arsonoacetic acid. Consequently, the well-dispersed arsonic acid-presenting SPIOs in water were obtained. We found that the dispersion state of the arsonic acid-presenting SPIOs can be sharply regulated by pH changes in the biological significant region. The well dispersion state of the arsonic acid-presenting SPIOs can be maintained at the neutral pH region. In contrast, the arsonic acid-presenting SPIOs can sensitively form the aggregation below pH 6.1. Moreover, these dispersion states can be controlled reversibly by the pH alteration in the narrow region.