Roles of partitioning‐defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells
Roles of partitioning‐defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells
复制标题
DOI：
10.1111/1440-1681.12794
复制
发表时间：
2017-09
影响因子：
2.9
通讯作者：
L. Ruan;Yanting Shen;Ziwen Lu;D. Shang;Zhicong Zhao;Yongjin Lu;Yanfang Wu;Yafei Zhang;Z. Tu;Hanqing Liu
中科院分区：
文献类型：
--
作者：
L. Ruan;Yanting Shen;Ziwen Lu;D. Shang;Zhicong Zhao;Yongjin Lu;Yanfang Wu;Yafei Zhang;Z. Tu;Hanqing Liu
分配缺陷蛋白6（Par 6）是细胞极性和稳态的关键调节因子，形成多组分复合物，不仅调节细胞极性和稳定细胞形态，而且还被证明参与癌细胞的增殖、迁移和侵袭。转化生长因子（TGF）-β和细胞外信号调节激酶（Erk）1/2途径是许多癌症中涉及Par 6的研究最彻底的途径。金硫代苹果酸盐已被用于破坏多组分复合物中Par 6和非典型蛋白激酶C之间的相互作用，并已被证明在体外和/或体内有效地阻断多种癌症（包括胰腺癌、前列腺癌和肺癌以及腺泡状横纹肌肉瘤）中的转化生长和转移。很可能随着关于Par 6在癌症起始、进展和转移中的关键作用的进一步揭示，将发现针对Par 6的靶向疗法，并在癌症治疗中在临床前和临床上证明有效。
A pivotal regulator of cell polarity and homeostasis, partitioning‐defective protein 6 (Par6) forms multicomponent complexes that not only regulate cell polarity and stabilize cell morphology, but have also been demonstrated to participate in the proliferation, migration and invasion of cancer cells. The transforming growth factor (TGF)‐β and extracellular signal‐regulated kinase (Erk) 1/2 pathways are the most thoroughly studied pathways involving Par6 in many cancers. Aurothiomalate has been used to disrupt the interaction between Par6 and atypical protein kinase C within the multicomponent complexes, and has been shown to effectively block transformed growth and metastasis in vitro and/or in vivo in a variety of cancers, including pancreatic, prostate and lung cancers, as well as alveolar rhabdomyosarcoma. It is likely that with further revelations regarding the critical roles of Par6 in cancer initiation, progression and metastasis, targeted therapies against Par6 will be discovered and prove effective preclinically, and hopefully clinically, in cancer treatment.