Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief
Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief
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DOI：
10.1038/sj.clpt.6100385
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发表时间：
2008-04-01
影响因子：
6.7
通讯作者：
Barale, R.
中科院分区：
文献类型：
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作者：
Campa, D.;Gioia, A.;Barale, R.
吗啡的药代动力学和药效学受多个多态性基因的控制，这可以解释观察到的疼痛缓解个体间差异的部分原因。我们专注于两个这样的基因：ABCB 1/MDR 1，吗啡生物利用度的主要决定因素，和OPRM 1，它编码的m-阿片受体，吗啡的主要作用部位。145例接受吗啡治疗的意大利籍患者进行ABCB 1/MDR 1单核苷酸多态性（SNP）C3435 T和OPRM 1 A80 G SNP基因分型。疼痛缓解变异性显著（P
The pharmacokinetics and pharmacodynamics of morphine are under the control of several polymorphic genes, which can account for part of the observed interindividual variation in pain relief. We focused on two such genes: ABCB1/MDR1, a major determinant of morphine bioavailability, and OPRM1, which encodes for the m-opioid receptor, the primary site of action for morphine. One hundred and forty-five patients of Italian origin undergoing morphine therapy were genotyped for the single-nucleotide polymorphism (SNP) C3435T of ABCB1/MDR1 and for the A80G SNP of OPRM1. Pain relief variability was significantly (P