Interval Estimation of the Effective Population Size from Heterozygote‐Excess in SNP Markers
Interval Estimation of the Effective Population Size from Heterozygote‐Excess in SNP Markers
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SNP 标记中杂合子过量的有效群体规模的区间估计
DOI：
10.1002/bimj.200900097
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发表时间：
2009
影响因子：
1.7
通讯作者：
T. Nomura
中科院分区：
文献类型：
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作者：
T. Nomura
有效种群规模Ne是种群遗传学和保护生物学中的一个重要参数。近年来，利用分子标记来估计Ne已引起人们的极大兴趣。虽然分子标记的点估计总体上可靠性较低，但单核苷酸多态(SNP)标记在广泛的基因组范围内的使用有望显著提高可靠性。在这项研究中，推导了一种已发表的方法，即杂合子过量方法，当它应用于SNP标记时，Ne的区间估计的表达式。应用条件方差理论推导了配子、一夫一妻制和一夫多妻制随机结合下Ne的置信度区间。随机模拟表明，所得到的置信度区间略显保守，但在实际应用中具有一定的实用价值。用一个猪品系的SNP标记的真实数据说明了这一结果。
The effective population size Ne is an important parameter in population genetics and conservation biology. In recent years, there has been great interest in the use of molecular markers to estimate Ne. Although the point estimates from molecular markers in general suffer from a low reliability, the use of single nucleotide polymorphism (SNP) markers over a wide range of genome is expected to remarkably improve the reliability. In this study, expressions were derived for interval estimates of Ne from one published method, the heterozygote‐excess method, when it is applied to SNP markers. The conditional variance theory is applied to the derivation of a confidence interval for Ne under random union of gametes, monogamy and polygyny. Stochastic simulation shows that the obtained confidence interval is slightly conservative, but fairly useful for practical applications. The result is illustrated with real data on SNP markers in a pig strain.