Theory and Experiments on Multi-Ion Permeation and Selectivity in the NaChBac Ion Channel
Theory and Experiments on Multi-Ion Permeation and Selectivity in the NaChBac Ion Channel
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DOI：
10.1142/s0219477519400078
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发表时间：
2019-06-01
影响因子：
1.8
通讯作者：
McClintock, P. V. E.
中科院分区：
文献类型：
--
作者：
Gibby, W. A. T.;Barabash, M. L.;McClintock, P. V. E.
离子通过生物离子通道的高选择性渗透是一个尚未解决的噪声和波动问题。在本文中，我们激励和介绍了一个非平衡和自洽的多物种动力学模型，表达的目的是比较与实验记录的电流与电压和浓度和提取重要的渗透参数。对于自洽性，模型在两种状态下的行为，即，选择性限制的线性响应，必须同意最近的结果来自平衡统计理论。动力学模型提供了一个很好的拟合数据，包括一个异常的摩尔分数效应的关键结果。
The highly selective permeation of ions through biological ion channels is an unsolved problem of noise and fluctuations. In this paper, we motivate and introduce a non-equilibrium and self-consistent multi-species kinetic model, with the express aims of comparing with experimental recordings of current versus voltage and concentration and extracting important permeation parameters. For self-consistency, the behavior of the model at the two-state, i.e., selective limit in linear response, must agree with recent results derived from an equilibrium statistical theory. The kinetic model provides a good fit to data, including the key result of an anomalous mole fraction effect.