Memory consolidation or transformation: context manipulation and hippocampal representations of memory
Memory consolidation or transformation: context manipulation and hippocampal representations of memory
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DOI：
10.1038/nn1880
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发表时间：
2007-05-01
影响因子：
25
通讯作者：
Sekeres, Melanie
中科院分区：
文献类型：
--
作者：
Winocur, Gordon;Moscovitch, Morris;Sekeres, Melanie
传统的观点认为，海马体对于记忆的保存是必不可少的，直到它们在新皮层中以原来的形式得到巩固。另一种观点认为，最初的记忆依赖于海马体和上下文，随着时间的推移，它会转变为一种更加图式化的、独立于海马体的记忆。通过在两个广泛用于研究记忆中海马-新皮层相互作用的协议中操纵上下文，我们找到了转换观点的证据。
The traditional view is that the hippocampus is necessary for retaining memories until they are consolidated in their original form in the neocortex. An alternative view is that the original memory, which is hippocampus- and context- dependent, becomes transformed with time to one that is more schematic and independent of the hippocampus. By manipulating context in two protocols that are widely used to investigate hippocampal- neocortical interactions in memory, we find evidence for the transformation view.