Prevalence of infection with dengue virus among international travelers
Prevalence of infection with dengue virus among international travelers
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DOI：
10.1001/archinte.157.20.2367
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发表时间：
1997-11-10
影响因子：
--
通讯作者：
Nothdurft, HD
中科院分区：
文献类型：
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作者：
Jelinek, T;Dobler, G;Nothdurft, HD
背景：登革热已被认为是游客的潜在危险。为了解登革热在国际旅行者中的感染情况，在德国某传染病门诊开展了一项前瞻性对照研究。方法：对130名临床上有登革热症状或近期病史(发热、头痛、肌肉关节痛或皮疹)的患者、95名与之匹配的腹泻患者和26名从未去过登革热流行国家的患者的血清样本进行登革病毒抗体检测。结果：130名症状相容的患者中有9名(6.9%)和95名腹泻对照组中1名(1%)登革热病毒抗体滴度升高。在这10名疑似登革热感染的患者中，6人去过泰国，2人去过马来西亚，1人去过印度尼西亚和巴西。结论：登革热病毒感染似乎是东南亚旅行者的现实威胁。通常与登革热有关的症状，如发烧、肌肉痛、关节痛和呕吐，在出现时可能有助于诊断，但没有典型症状并不排除感染。
Background: Dengue has been recognized as a potential hazard to tourists. A prospective, controlled study in the outpatient clinic of a German infectious disease clinic was conducted to assess the prevalence of dengue virus infection among international travelers.Methods: Serum samples from 130 patients with signs or recent history clinically compatible with dengue (fever, headache, muscle and joint pain, or rash), 95 matched controls with diarrhea, and 26 patients who never visited a country endemic for dengue were investigated.Results: Nine (6.9%) of the 130 patients with compatible symptoms and 1 (1%) of the 95 controls with diarrhea developed rising antibody titers against dengue virus. Of these 10 patients with probable dengue infection, 6 had been to Thailand, 2 to Malaysia, and 1 each to Indonesia and Brazil.Conclusions: Infection with dengue virus appears to be a realistic threat to travelers to Southeast Asia. Symptoms commonly associated with dengue, such as fever, myalgia, arthralgia, and vomiting, can be helpful for diagnosis when present, but the absence of typical symptoms does not exclude infection.