Rapid Eye Movement Sleep Behavior Disorder
Rapid Eye Movement Sleep Behavior Disorder
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DOI：
10.13078/jsm.18001
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发表时间：
2018-06
期刊：
影响因子：
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通讯作者：
Sooyeoun You;Soo Myeong Jeon;Y. Cho
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文献类型：
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作者：
Sooyeoun You;Soo Myeong Jeon;Y. Cho
收稿日期 2018年1月10日 修订日期 2018年1月24日 接受日期 2018年1月26日 通信地址 Yong Won Cho, MD, Ph.D. Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, 56 Dalseong-ro, Jung-gu, Daegu 41931, Korea 电话：+82-53-250-7831 传真： +82-53-250-7840 电子邮件：neurocho@gmail.com 快速眼动 (REM) 睡眠行为障碍 (RBD) 是一种异常睡眠，其特征是由于快速眼动睡眠期间发生的异常行为导致睡眠中断或创伤。 RBD 的病理生理学被认为是脑干回路功能障碍，导致快速眼动睡眠期间骨骼肌肌张力丧失。 RBD 的诊断需要通过多导睡眠图确认快速眼动睡眠且无肌张力不稳。 RBD的管理不仅包括药物治疗，还包括预防RBD损伤以及后续可能发生的神经退行性疾病的随访。 RBD 被认为是与 α-突触核蛋白病相关的神经退行性疾病的前驱阶段，例如帕金森病或多系统萎缩。本文综述了 RBD 的症状、流行病学、诊断和治疗、神经退行性疾病的相关性以及最新的研究趋势。睡眠医学杂志 2018;15(1):1-7
Received January 10, 2018 Revised January 24, 2018 Accepted January 26, 2018 Address for correspondence Yong Won Cho, MD, PhD Department of Neurology, Dongsan Medical Center, Keimyung University School of Medicine, 56 Dalseong-ro, Jung-gu, Daegu 41931, Korea Tel: +82-53-250-7831 Fax: +82-53-250-7840 E-mail: neurocho@gmail.com Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by sleep interruption or trauma due to abnormal behaviors that occur during REM sleep. The pathophysiology of RBD is known to be a dysfunction of brainstem circuit that causes the loss of skeletal muscle atonia during REM sleep. The diagnosis of RBD is needed to confirm REM sleep without atonia in the polysomnography. The management of RBD includes not only drug treatment, but also to prevent injury from RBD and to followup on neurodegenerative diseases that may occur later. RBD is thought to be a prodromal stage of neurodegenerative disease associated with α-synucleoinopathy, such as Parkinson’s Disease or multiple system atrophy. This article reviews the symptoms, epidemiology, diagnosis and treatment of RBD, the relevance of neurodegenerative diseases, and recent research trends. J Sleep Med 2018;15(1):1-7