Reduction in penis size and plasma testosterone concentrations in juvenile alligators living in a contaminated environment
Reduction in penis size and plasma testosterone concentrations in juvenile alligators living in a contaminated environment
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DOI：
10.1006/gcen.1996.0005
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发表时间：
1996-01-01
影响因子：
2.7
通讯作者：
Percival, HF
中科院分区：
文献类型：
--
作者：
Guillette, LJ;Pickford, DB;Percival, HF
脊椎动物雄性生殖道和外生殖器的发育依赖于胚胎发育和出生后生长期间雄激素浓度的升高。我们观察到，与伍德拉夫湖上类似大小的动物相比，生活在阿波普卡湖上的少年短吻鳄的阴茎尺寸显着较小（平均减少24%），血浆睾酮浓度较低（浓度低70%）。除了较小的阴茎，血浆睾酮浓度和阴茎大小之间没有关系存在于男性从阿波普卡湖，而一个积极的关系存在男性从伍德拉夫湖。众所周知，阿波普卡湖上的短吻鳄脂肪中储存着高浓度的抗雄激素DDT分解产物p，p '-DDE。我们提出了一些假设，可以解释的青少年男性生活在阿波普卡湖的表型的修改。这些表型改变包括阴茎变小、血浆雄激素浓度降低以及阴茎对血浆雄激素缺乏反应性。(C)出版社：Academic Press，Inc.
The development of the male reproductive ducts and external genitalia in vertebrates is dependent on elevated androgen concentrations during embryonic development and the period of postnatal growth. We have observed that a population of juvenile alligators living on Lake Apopka exhibit significantly smaller penis size (24% average decrease) and lower plasma concentrations of testosterone (70% lower concentrations) when compared to animals of similar size on Lake Woodruff. In addition to smaller phalli, no relationship exists between plasma testosterone concentrations and penile size in males from Lake Apopka, whereas a positive relationship exists for males from lake Woodruff. The alligators on Lake Apopka are known to have elevated concentrations of the antiandrogenic DDT breakdown product p,p'-DDE stored in their fat. We suggest a number of hypotheses that could explain the modification in the phenotype of the juvenile male living in Lake Apopka. These modifications in phenotype include a smaller penis size, lower plasma androgen concentrations, and lack of responsiveness of the penis to the plasma androgens present. (C) 1996 Academic Press, Inc.