Anti-tumor effects of Atractylenolide I on bladder cancer cells
Anti-tumor effects of Atractylenolide I on bladder cancer cells
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DOI：
10.1186/s13046-016-0312-4
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
Qi Ma
中科院分区：
文献类型：
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作者：
Rui Yu;Baixia Yu;Junfeng Cheng;Xiuyi Lv;Zijie Yang;Yu Cheng;Qi Ma
ATR-1 inhibited bladder cancer cell proliferation, arrested cell cycle in G2/M phase through up-regulation of p21 and down-regulation of cyclin B1, CDK1 and Cdc25c. Meanwhile, ATR-1 also triggered cellular apoptosis depending on the activation of mitochondrial apoptotic pathway. Mechanism investigation indicated that ATR-1 exerts its anti-tumor effect also relies on the inhibition of PI3K/Akt/mTOR signaling pathway. Finally, mice studies showed that ATR-1 blocked the T-24 or 253J-induced xenograft tumor growth without noticeable toxicity.
