The effect of hemispheric synchronization on intraoperative analgesia
The effect of hemispheric synchronization on intraoperative analgesia
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DOI：
10.1213/01.ane.0000096181.89116.d2
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发表时间：
2004-02-01
影响因子：
5.7
通讯作者：
Roth, R
中科院分区：
文献类型：
--
作者：
Lewis, AK;Osborn, IP;Roth, R
在这项双盲随机研究中，我们试图证实接受全身麻醉的患者在手术期间暴露于半球同步（semi - sync）音乐录音具有较小的镇痛需求，正如先前的研究所建议的那样。采用双谱指数监测调节催眠深度，采用血流动力学变量确定镇痛剂量。同意的患者接受腹腔镜减肥或单节段腰椎间盘手术。经气管插管及戴上耳机后，测定基线心率及动脉血压。在目标双谱指数范围40-60的基础上，滴定异氟醚以维持镇静，并在心率和收缩压增加的情况下增加25马克芬太尼。与对照组相比，接受半同步治疗的肥胖患者需要的芬太尼减少了三分之一(平均[SD]: 0.015 [0.01] vs 0.024马克。公斤(1)。min(-1) [0.01]) （P = 0.009）。有趣的是，实验组和对照组的腰椎患者需要相似量的芬太尼（0.012 [0.01]vs 0.015马克杯）。公斤(1)。分钟(1)[0.01])。半同步和空白胶带患者的潮末异氟烷浓度相似(肥胖，0.74% (0.14)vs 0.77% (0.21)；腰椎，0.36% [0.16]vs 0.39%[0.12])。本研究中的肥胖患者表明，半同步可能是一种创新的术中镇痛补充。
In this double-blinded randomized study, we sought to confirm that patients undergoing general anesthesia who were exposed to a hemispheric synchronization (Hemi-Sync) musical recording during surgery had a smaller analgesia requirement, as was suggested in a previous study. Bispectral index monitoring was used to adjust depth of hypnosis, and hemodynamic variables were used to determine analgesia administration. Consented patients underwent either laparoscopic bariatric or one-level lumbar disk surgery. After endotracheal intubation and application of headphones, baseline heart rate and arterial blood pressure were established. Isoflurane was titrated to maintain sedation on the basis of a target bispectral index range of 40-60, and 25-mug increments of fentanyl were administered in response to increases in heart rate and systolic arterial blood pressure. Bariatric patients who listened to Hemi-Sync required one-third less fentanyl than the control roup (mean [SD]: 0.015 [0.01] vs 0.024 mug . kg(-1) . min(-1) [0.01]) (P = 0.009). It is interesting to note that lumbar patients in the experimental and control groups required similar amounts of fentanyl (0.012 [0.01] vs 0.015 mug . kg(-1) . min(-1) [0.01]). End-tidal isoflurane concentration was similar for Hemi-Sync and blank-tape patients (bariatric, 0.74% (0.14) vs 0.77% (0.21); lumbar, 0.36% [0.16] vs 0.39% [0.12]). The bariatric patients in this study demonstrated that Hemi-Sync may be an innovative intraoperative supplement to analgesia.