The role of vitamin D in prevention and treatment of infection.
The role of vitamin D in prevention and treatment of infection.
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DOI：
10.2174/18715281113129990046
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发表时间：
2013-08
期刊：
影响因子：
--
通讯作者：
Ginde AA
中科院分区：
文献类型：
--
作者：
Gunville CF;Mourani PM;Ginde AA
维生素D因其在维持骨密度方面的经典作用而广为人知。然而，维生素D还通过调节先天免疫系统和获得性免疫系统，影响重要内源性抗菌肽的产生，如长春花素，调节炎症级联，对人体免疫系统产生重要的非经典影响。在成人和儿童中的多项流行病学研究表明，维生素D缺乏与感染风险增加和更严重的感染有关，特别是呼吸道感染。尽管维生素D可以改善感染免疫反应的确切机制仍在评估中，但补充维生素D预防和辅助治疗感染的试验正在进行中。鉴于其对免疫系统和炎症级联反应的影响，维生素D未来可能在预防和治疗感染方面发挥重要作用。
Vitamin D is well known for its classic role in the maintenance of bone mineral density. However, vitamin D also has an important “non-classic” influence on the body’s immune system by modulating the innate and adaptive immune system, influencing the production of important endogenous antimicrobial peptides such as cathelicidin, and regulating the inflammatory cascade. Multiple epidemiological studies in adults and children have demonstrated that vitamin D deficiency is associated with increased risk and greater severity of infection, particularly of the respiratory tract. Although the exact mechanisms by which vitamin D may improve immune responses to infection continue to be evaluated, vitamin D supplementation trials of prevention and adjunct therapy for infection are underway. Given its influence on the immune system and inflammatory cascade, vitamin D may have an important future role in the prevention and treatment of infection.