Resistance Training at Eight-Repetition Maximum Reduces the Inflammatory Milieu in Elderly Women
Resistance Training at Eight-Repetition Maximum Reduces the Inflammatory Milieu in Elderly Women
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DOI：
10.1249/mss.0b013e3181b11ab7
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发表时间：
2010-02-01
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影响因子：
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通讯作者：
Timmerman, Kyle L.
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作者：
Phillips, Melody D.;Flynn, Michael G.;Timmerman, Kyle L.
菲利普斯、M.D.M.G.弗林、B.K.麦克法兰、L.K.斯图尔特和K.L.蒂默曼。最多八次重复的阻力训练可减少老年妇女的炎症环境。医学。科学。体育锻炼，卷。 42，第 2 期，第 314-325 页，2010 年。简介/目的：炎症细胞因子与年龄和缺乏活动相关的疾病有关。我们研究了中高强度抗阻训练 (RT) 对老年女性循环中炎症细胞因子（白细胞介素 6 (IL-6) 和 1β (IL-1β) 以及肿瘤坏死因子 α (TNF-α)）以及脂多糖 (LPS) 刺激的全血的影响。方法：以前久坐的女性（72 +/- 6.1 岁）根据激素替代方案进行分组：传统雌激素/黄体酮（HRT n = 12）、选择性雌激素受体调节剂（SER，n = 7）、不激素替代（NHR，n = 9）或不服用激素替代的非运动对照组（CON，n = 7）。 HRT、SER 的参与者。 NHR 组接受训练（三组，10 次练习，最多重复 8 次 (8RM)）3 d.wk(-1)。而 CON 组的参与者则保持“正常”活动 10 周。参与者在 RT 之前（BT）和 RT 之后（AT）进行了一轮阻力运动（RE 为 8RM；HRT、SER 和 NHR 组）或安静地坐着 (CON)，以评估训练对 RE 急性反应的影响。在运动前 (PR)、运动后 (PO) 和运动后 2 小时（2H；静息 CON 的相同时间点）采集血样。结果：激素状态对因变量没有影响，因此 HRT、SER 也没有影响。和 NHR 组被分为一个运动组（EX，it = 28）并与 CON 进行比较。 RT 使静息血清 TNF-α 水平显着降低 37%。 RT 还减少了所有时间点（PR、PO 和 2H；每个单核细胞）LPS 刺激的 IL-6、IL-1 beta 和 TNF-a 的产生。急性 RE 短暂增加了血浆 TNF-α，但减弱了 CON 中观察到的 LPS 刺激的炎症细胞因子的昼夜增加。与 BT 相比，EX 的钝化效果明显高于 AT。 RE 还导致血浆 IL-6 增加，而 AT 显着降低（BT：PR = 1.6 +/- 0.5 PO = 2.8 +/- 0.5；AT：PR = 1.8 +/- 0.3，PO = 2.4 +/- 0.3）。结论：我们发现，10 周的中高强度 RT 1) 减少了全身炎症环境，2) 消除了以前久坐的老年女性运动引起的循环 IL-6。
PHILLIPS, M. D. M. G. FLYNN, B. K. MCFARLIN, L. K. STEWART, and K. L. TIMMERMAN. Resistance Training at Eight-Repetition Maximum Reduces the Inflammatory Milieu in Elderly Women. Med. Sci. Sports Exerc., Vol. 42, No. 2, pp. 314-325, 2010. Introduction/Purpose: Inflammatory cytokines are associated with age- and inactivity-related diseases. We examined the influence of moderate- to high-intensity resistance trainings (RT) on inflammatory cytokines (interleukin 6 (IL-6) and 1 beta (IL-1 beta) and tumor necrosis factor alpha (TNF-alpha)) in circulation and lipopolysaccharide (LPS)-stimulated whole blood in elderly women. Method: Previously sedentary women (72 +/- 6.1 yr) were grouped according to their hormone replacement regimen: traditional estrogen/progesterone (HRT n = 12), selective estrogen receptor modulator (SER, n = 7), no hormone replacement (NHR, n = 9), or nonexercise control group taking no hormone replacement (CON, n = 7). Participants in the HRT, SER. and NHR groups trained (three sets, 10 exercises at eight-repetition maximum (8RM)) 3 d.wk(-1). whereas participants in the CON group maintained their "normal" activity for 10 wk. Participants performed a bout of resistance exercise (RE at 8RM; HRT, SER, and NHR groups) or sat quietly (CON) before (BT) and after (AT) RT to assess the influence of training on the acute responses to RE. Blood samples were obtained preexercise (PR), postexercise (PO), and 2 h postexercise (2H; same time points for resting CON). Results: Hormone status had no influence on dependent variables, so HRT, SER. and NHR groups were collapsed into one exercise group (EX, it = 28) and compared with CON. RT significantly reduced resting serum TNF-alpha level by 37%. RT also reduced LPS-stimulated production of IL-6, IL-1 beta, and TNF-a at all time points (PR, PO, and 2H; per monocyte). Acute RE transiently increased plasma TNF-alpha, but blunted the circadian increase in LPS-stimulated inflammatory cytokines observed in CON. The blunting effect in EX was significantly greater AT compared with BT. RE also resulted in an increase in plasma IL-6, which was significantly reduced AT (BT: PR = 1.6 +/- 0.5 PO = 2.8 +/- 0.5; AT: PR = 1.8 +/- 0.3, PO = 2.4 +/- 0.3). Conclusions: We found that 10 wk of moderate- to high-intensity RT 1) reduced the systemic inflammatory milieu and 2) abrogated exercise-induced circulating IL-6 in previously sedentary elderly women.