Effects of past noninjection drug abuse upon executive function and working memory in HIV infection
Effects of past noninjection drug abuse upon executive function and working memory in HIV infection
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DOI：
10.1076/jcen.25.7.893.16489
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发表时间：
2003-10-01
影响因子：
2.2
通讯作者：
Bornstein, RA
中科院分区：
文献类型：
--
作者：
Basso, MR;Bornstein, RA
在294名男同性恋者中，评估了既往非注射药物滥用/依赖和HIV疾病状况对执行功能测量的交互影响。参与者根据艾滋病毒状况和药物使用诊断进行分层，从而产生4(血清阴性、无症状血清阳性、有症状血清阳性、艾滋病定义疾病)×2(从未滥用药物、既往药物使用障碍)设计。HIV状态对威斯康星卡片分类测验、拉夫图形流利性测验、连线测验B和总受损表演数有显著的主效应。分析显示，艾滋病定义为疾病的男性比其他三组表现更差。吸毒史对神经行为功能无显著影响，吸毒史对神经行为功能的影响较小。这些数据表明，在艾滋病毒感染中，以前使用药物几乎不会产生任何残余的认知障碍。
Interactive effects of past noninjection drug abuse/dependence and HIV disease status upon measures of executive function were assessed in a group of 294 homosexual men. Participants were stratified according to HIV status and substance use diagnoses, thereby yielding a 4 (seronegative, asymptomatic seropositive, symptomatic seropositive, and AIDS defining illness) x 2 (never abused drugs, previous substance use disorder) design. Significant main effects of HIV status were found on the Wisconsin Card Sorting Test, Ruff Figural Fluency Test, Trail Making Test B, and total number of impaired performances. Analyses revealed that men with AIDS defining illness performed worse than the other three groups. Drug use history had no significant effect upon neurobehavioral function, and effect sizes for drug abuse history were small. The data suggest that prior drug use yields little if any residual cognitive impairment in HIV infection.