Sympathetic and parasympathetic activity in cancer-related fatigue: more evidence for a physiological substrate in cancer survivors.
Sympathetic and parasympathetic activity in cancer-related fatigue: more evidence for a physiological substrate in cancer survivors.
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DOI：
10.1016/j.psyneuen.2011.02.005
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发表时间：
2011-09
影响因子：
3.7
通讯作者：
Kiecolt-Glaser, Janice K.
中科院分区：
文献类型：
--
作者：
Fagundes, Christopher P.;Murray, David M.;Hwang, Beom Seuk;Gouin, Jean-Philippe;Thayer, Julian F.;Sollers, John J., III;Shapiro, Charles L.;Malarkey, William B.;Kiecolt-Glaser, Janice K.
关键词：
疲劳是癌症幸存者的一个值得注意的临床问题，了解其病理生理学是重要的。本研究评估了乳腺癌幸存者疲劳与交感神经和副交感神经系统活动之间的关系。去甲肾上腺素和心率变异性（HRV）进行了评估，在休息时，以及期间和之后的标准化实验室语音和心算压力。参与者是109名在过去两年中完成0-IIIA期乳腺癌治疗的女性，至少在手术，放疗或化疗后两个月，以最后发生者为准。与疲劳程度较低的女性相比，报告疲劳程度较高的女性在压力源前后的去甲肾上腺素水平显著较高，心率变异性较低。疲劳与治疗或疾病变量（包括治疗类型、癌症分期、自诊断以来的时间和自治疗以来的时间）无关。重要的是，HRV和癌症相关疲劳之间的关系是相当大的。基于已经证明与年龄相关的特征性HRV下降的研究，我们的研究结果表明，疲劳和非疲劳癌症幸存者之间存在20年的差异，这增加了疲劳可能意味着加速衰老的可能性。此外，较低的HRV和升高的去甲肾上腺素与许多不良健康结果相关;因此，疲劳也可能表明需要提高对其他健康威胁的警惕。
Fatigue is a notable clinical problem in cancer survivors, and understanding its pathophysiology is important. This study evaluated relationships between fatigue and both sympathetic and parasympathetic nervous system activity in breast cancer survivors. Norepinephrine and heart rate variability (HRV) were evaluated at rest, as well as during and after a standardized laboratory speech and mental arithmetic stressor. The participants, 109 women who had completed treatment for stage 0-IIIA breast cancer within the past two years, were at least two months post surgery, radiation or chemotherapy, whichever occurred last. Women who reported more fatigue had significantly higher norepinephrine and lower HRV before and after the stressor than their less fatigued counterparts. Fatigue was not related to treatment or disease variables including treatment type, cancer stage, time since diagnosis, and time since treatment. Importantly, the relationship between HRV and cancer-related fatigue was sizeable. Based on research that has demonstrated characteristic age-related HRV decrements, our findings suggest a 20 year difference between fatigued and non-fatigued cancer survivors, raising the possibility that fatigue may signify accelerated aging. Furthermore, lower HRV and elevated norepinephrine have been associated with a number of adverse health outcomes; accordingly, fatigue may also signal the need for increased vigilance to other health threats.
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影响因子：
2.4
作者：
EGELUND, N
通讯作者：
EGELUND, N
影响因子：
3.2
作者：
Brook, RD;Julius, S
通讯作者：
Julius, S
影响因子：
3.3
作者：
Bower, JE;Ganz, PA;Aziz, N
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影响因子：
2.8
作者：
Antelmi, I;De Paula, RS;Grupi, CJ
通讯作者：
Grupi, CJ
DOI：
10.1073/pnas.0438019100
发表时间：
2003-02-18
影响因子：
11.1
作者：
Bierhaus, A;Wolf, J;Nawroth, PP
通讯作者：
Nawroth, PP