Ocular Vascular Diseases: From Retinal Immune Privilege to Inflammation.
Ocular Vascular Diseases: From Retinal Immune Privilege to Inflammation.
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DOI：
10.3390/ijms241512090
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发表时间：
2023-07-28
影响因子：
5.6
通讯作者：
Sun, Ye
中科院分区：
文献类型：
--
作者：
Wang, Xudong;Wang, Tianxi;Lam, Enton;Alvarez, David;Sun, Ye
关键词：
眼睛是一种免疫特权组织，它将视觉系统与局部和全身免疫刺激隔离开来，以保持高度特化的视网膜神经细胞的稳态功能。如果免疫特权被破坏，免疫刺激将侵入眼睛，随后引发急性炎症反应。局部小胶质细胞变得活跃并释放大量免疫因子以保护视网膜神经细胞的完整性。虽然急性炎症反应对于控制和根除对眼睛的损害是必要的，但慢性炎症可引起视网膜组织损伤和细胞功能障碍，导致眼部疾病和视力丧失。本文综述了视网膜免疫特权的特点和视网膜免疫特权失效时激活的关键炎症反应、因素和细胞内通路，并重点介绍了近年来眼免疫和眼血管疾病（包括早产儿视网膜病变、年龄相关性黄斑变性和糖尿病视网膜病变）的临床和研究进展。
The eye is an immune privileged tissue that insulates the visual system from local and systemic immune provocation to preserve homeostatic functions of highly specialized retinal neural cells. If immune privilege is breached, immune stimuli will invade the eye and subsequently trigger acute inflammatory responses. Local resident microglia become active and release numerous immunological factors to protect the integrity of retinal neural cells. Although acute inflammatory responses are necessary to control and eradicate insults to the eye, chronic inflammation can cause retinal tissue damage and cell dysfunction, leading to ocular disease and vision loss. In this review, we summarized features of immune privilege in the retina and the key inflammatory responses, factors, and intracellular pathways activated when retinal immune privilege fails, as well as a highlight of the recent clinical and research advances in ocular immunity and ocular vascular diseases including retinopathy of prematurity, age-related macular degeneration, and diabetic retinopathy.
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影响因子：
5.6
作者：
Bonfiglio V;Platania CBM;Lazzara F;Conti F;Pizzo C;Reibaldi M;Russo A;Fallico M;Ortisi E;Pignatelli F;Longo A;Avitabile T;Drago F;Bucolo C
通讯作者：
Bucolo C
影响因子：
4.7
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通讯作者：
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影响因子：
2.8
作者：
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通讯作者：
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影响因子：
4.3
作者：
Rajamani U;Jialal I
通讯作者：
Jialal I
DOI：
10.5935/1676-2444.20170001
发表时间：
2017-02-01
影响因子：
--
作者：
Cardoso, Jéssica F.;Gomes, Karina B.;Domingueti, Caroline P.
通讯作者：
Domingueti, Caroline P.