High-sensitivity intravascular photoacoustic imaging of lipid-laden plaque with a collinear catheter design.
High-sensitivity intravascular photoacoustic imaging of lipid-laden plaque with a collinear catheter design.
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DOI：
10.1038/srep25236
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发表时间：
2016-04-28
影响因子：
4.6
通讯作者：
Cheng JX
中科院分区：
文献类型：
--
作者：
Cao Y;Hui J;Kole A;Wang P;Yu Q;Chen W;Sturek M;Cheng JX
高度敏感的导管探头对于导管血管内光声成像至关重要。在这里，我们首次提出了一种基于入射光波和光声产生的声波在微型导管壳体内共线排列的光声导管探头设计。这种外径为1.6 mm的共线导管设计在D2O介质中提供了在bbb60mm成像深度上光学和声波之间的高效重叠。利用实验室研制的500 Hz光学参量振荡器，输出波长为1.7 μm的纳秒级光脉冲，对C-H键进行谐波激发，展示了载脂动脉粥样硬化斑块和血管周围脂肪的血管内光声成像。除了血管内成像外，本发明的导管设计将有利于其他光声应用，如基于针的肌肉内成像。
A highly sensitive catheter probe is critical to catheter-based intravascular photoacoustic imaging. Here, we present a photoacoustic catheter probe design on the basis of collinear alignment of the incident optical wave and the photoacoustically generated sound wave within a miniature catheter housing for the first time. Such collinear catheter design with an outer diameter of 1.6 mm provided highly efficient overlap between optical and acoustic waves over an imaging depth of >6 mm in D2O medium. Intravascular photoacoustic imaging of lipid-laden atherosclerotic plaque and perivascular fat was demonstrated, where a lab-built 500 Hz optical parametric oscillator outputting nanosecond optical pulses at a wavelength of 1.7 μm was used for overtone excitation of C-H bonds. In addition to intravascular imaging, the presented catheter design will benefit other photoacoustic applications such as needle-based intramuscular imaging.