Daily text message assessments of 6-mercaptopurine adherence and its proximal contexts in adolescents and young adults with leukemia: A pilot study.
Daily text message assessments of 6-mercaptopurine adherence and its proximal contexts in adolescents and young adults with leukemia: A pilot study.
复制标题
DOI：
10.1002/pbc.28767
复制
发表时间：
2021-02
影响因子：
3.2
通讯作者：
Barakat, Lamia P.
中科院分区：
文献类型：
--
作者：
Psihogios, Alexandra M.;Li, Yimei;Ahmed, Annisa;Huang, Jing;Kersun, Leslie S.;Schwartz, Lisa A.;Barakat, Lamia P.
这项初步研究探讨了在患有白血病的青少年和年轻成人（AYA）中实施基于文本的口服化疗依从性评估的可行性和可接受性。
被开具维持性6 - 巯基嘌呤（6MP）处方的AYA接受了为期28天的每日短信调查，并使用电子药瓶。短信调查评估了6MP的依从性以及相关情境因素（例如，情绪）。可行性通过招募/留存率、调查完成率、成本和技术问题来定义。28天结束后，AYA完成了一项可接受性调查。二次分析比较了短信调查和电子药瓶的依从率，并探究了情境因素与6MP不依从性之间的日常关联。
18名AYA参与（平均年龄 = 18岁，范围15 - 22岁）并完成了研究流程（招募率和留存率均为100%）。依从性调查完成率很高（平均 = 88.9%），技术成本为204.00美元，且几乎没有技术问题。AYA报告对调查满意度很高，并认为这些调查是一种有用的用药提醒。虽然没有显著相关性，但调查和电子药瓶的依从性数据在大多数日子里是一致的（>90%）。探索性分析表明，AYA更有可能在周末（优势比 = 2.33，P = 0.048）以及在其依从动机（优势比 = 0.28，P = 0.047）和负面情绪（优势比 = 3.92，P = 0.02）较自身平常状态变差的日子里漏服6MP。
对于患有白血病的AYA来说，每日基于文本的调查是一种可行且可接受的进行药物依从性评估的方法，并且可以作为一种短期干预措施。为了开发个性化的移动健康干预措施，研究结果还强调了研究6MP不依从性的时变预测因素的必要性。
This pilot study explored the feasibility and acceptability of implementing text-based assessments of oral chemotherapy adherence in adolescents and young adults (AYA) with leukemia. AYA prescribed maintenance 6-mercaptopurine (6MP) received daily text message surveys and utilized an electronic pill bottle for 28 days. Text surveys assessed 6MP adherence and contextual associates (eg, mood). Feasibility was defined by recruitment/retention rates, survey completion rates, cost, and technical issues. After the 28-day period, AYA completed an acceptability survey. Secondary analyses compared text survey and electronic pill bottle adherence rates, and explored the daily associations between contextual factors and 6MP nonadherence. Eighteen AYA enrolled (M age = 18, range 15–22) and completed study procedures (100% recruitment and retention rates). Adherence survey completion rates were high (M = 88.9%), the technology cost was $204.00, and there were few technical issues. AYA reported high satisfaction with the surveys and perceived them as a helpful medication reminder. While not significantly correlated, survey and electronic pill bottle adherence data converged on the majority of days (>90%). Exploratory analyses showed that AYA were more likely to miss a dose of 6MP on weekends (OR = 2.33, P = .048) and on days when their adherence motivation (OR = 0.28, P = .047) and negative affect (OR = 3.92, P = .02) worsened from their own typical functioning. For AYA with leukemia, daily text-based surveys are a feasible and acceptable method for delivering medication adherence assessments, and may operate as a short-term intervention. To develop personalized mobile health interventions, findings also highlighted the need to study time-varying predictors of 6MP nonadherence.
登录
查看更多内容
影响因子：
3.2
作者：
Hsieh, HF;Shannon, SE
通讯作者：
Shannon, SE
DOI：
10.1016/j.ejon.2015.08.007
发表时间：
2016-02
期刊：
European journal of oncology nursing : the official journal of European Oncology Nursing Society
影响因子：
--
作者：
McGrady ME;Brown GA;Pai AL
通讯作者：
Pai AL
影响因子：
4.2
作者：
Dunton, Genevieve F.;Huh, Jimi;Pentz, Mary Ann
通讯作者：
Pentz, Mary Ann
影响因子：
4.2
作者：
Mulvaney, Shelagh A.;Rothman, Russell L.;Johnson, Kevin B.
通讯作者：
Johnson, Kevin B.
影响因子：
3.7
作者：
Finitsis DJ;Pellowski JA;Johnson BT
通讯作者：
Johnson BT