Temporal changes in the endoscopic frequency of new cases of Barrett's esophagus in an australian health region
Temporal changes in the endoscopic frequency of new cases of Barrett's esophagus in an australian health region
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DOI：
10.1111/j.1572-0241.2006.00548.x
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发表时间：
2006-06-01
影响因子：
9.8
通讯作者：
Whiteman, David C.
中科院分区：
文献类型：
--
作者：
Kendall, Bradley J.;Whiteman, David C.
目的：近几十年来，被诊断患有巴雷特食管（BE）的患者数量有所增加，尽管来自欧洲和北美以外人群的数据很少。这一增长对卫生资源的利用和费用产生了重大影响。我们试图确定1990 - 2002年期间澳大利亚人群中BE新发病例内镜频率的变化。方法：我们确定了1990年、1998年和2002年澳大利亚健康地区新发BE的所有患者。BE病例分为短节段（SSBE）（<3 cm）、长节段（>= 3 cm）或长度不明。我们比较了三个时间段的食管胃镜检查（EGD）总数和BE新发病例数。结果：1990年至2002年，BE新发病例的内镜频率从2.9/1000例内镜检查增加到18.9/1000例内镜检查（p <0.001）。增加最多的是SSBE，从1990年的无新病例增加到2002年的每1 000 EGD 6.2例新病例。相比之下，在同一时期，长节段BE减少了17%（2.3 - 1.9例新发病例/1，000 EGD）。1990年进行了3，090例EGD，1998年为3，518例，2002年为2，593例，比前8年增加了14（p <0.001），在随后的4年中下降了26（p <0.001）。在接受EGD的澳大利亚人群中，BE（特别是SSBE疾病）新发病例的内镜频率和绝对数量，在1990年至2002年期间大幅增加。被诊断患有BE的患者的频率增加具有广泛的未来经济和临床意义。
OBJECTIVES: The number of patients diagnosed with Barrett's esophagus (BE) has increased in recent decades, although data from populations outside Europe and North America are scarce. This increase has significant implications for health resource utilization and costs. We sought to determine changes in the endoscopic frequency of new cases of BE in an Australian population during the period 1990-2002.METHODS: We identified all persons newly diagnosed with BE in an Australian health region in 1990, 1998, and 2002. BE cases were categorized as short segment (SSBE) (< 3 cm), long segment (>= 3 cm), or undefined length. We compared the total number of esophagogastroduodenoscopies (EGD) and the number of new cases of BE for the three time periods.RESULTS: Between 1990 and 2002, the endoscopic frequency of new cases of BE increased from 2.9 to 18.9 per 1,000 endoscopies (p < 0.001). The greatest increase was for SSBE, increasing from no new cases in 1990 to 6.2 new cases per 1,000 EGD in 2002. In contrast there was a 17% decrease (2.3-1.9 new cases per 1,000 EGD) for long segment BE during the same period. There were 3,090 EGDs undertaken in 1990, 3,518 in 1998, and 2,593 in 2002, an increase of 14% over the first 8-yr interval (p < 0.001), and a decline of 26% over the subsequent 4 yr (p < 0.001).CONCLUSIONS: In an Australian population undergoing EGD, the endoscopic frequency and absolute number of new cases of BE, particularly SSBE disease, has increased significantly between 1990 and 2002. This increased frequency of patients diagnosed with BE has broad future economic and clinical implications.