Isotype and antigen specificity of pertussis agglutinins following whole-cell pertussis vaccination and infection with Bordetella pertussis
Isotype and antigen specificity of pertussis agglutinins following whole-cell pertussis vaccination and infection with Bordetella pertussis
复制标题
全细胞百日咳疫苗接种和百日咳博德特氏菌感染后百日咳凝集素的同种型和抗原特异性
DOI：
10.1128/iai.62.3.1118-1120.1994
复制
发表时间：
1994
影响因子：
3.1
通讯作者：
B. Meade
中科院分区：
文献类型：
--
作者：
C. Mink;C. H. O'Brien;S. Wassilak;A. Deforest;B. Meade
已证明凝集素滴度升高与全细胞百日咳疫苗接种后的疾病保护相关，但人类凝集抗体的同种型和抗原特异性尚不清楚。在 13 项免疫测定中，经培养证实的百日咳博德特氏菌感染后（R' = 0.79；P < 0.0001）和全细胞百日咳疫苗接种后（R' = 0.87，P < 0.0001），免疫球蛋白 G 抗菌毛抗体与凝集素滴度具有最强的相关性。
Elevated agglutinin titers have been shown to correlate with protection from disease following whole-cell pertussis vaccination, but the isotype and antigen specificity of human agglutinating antibodies is unknown. In 13 immunoassays, immunoglobulin G antifimbria antibodies had the strongest correlation with agglutinin titers following culture-proven infection with Bordetella pertussis (R' = 0.79; P < 0.0001) and following whole-cell pertussis vaccination (R' = 0.87, P < 0.0001).