α1-Adrenoceptor blocker naftopidil improves sleep disturbance with reduction in nocturnal urine volume
α1-Adrenoceptor blocker naftopidil improves sleep disturbance with reduction in nocturnal urine volume
复制标题
α1-肾上腺素受体阻滞剂萘哌地尔通过减少夜间尿量改善睡眠障碍
作者：
O. Yokoyama;Y. Aoki;A. Tsujimura;T. Takao;M. Namiki;A. Okuyama
ObjectivesTo探讨α1受体阻滞剂改善尿失禁的机制，我们使用频率/容积图（FVC）研究α1受体阻滞剂萘哌地尔是否对伴有睡眠障碍的尿失禁起作用。入选标准如下：I-PSS评分8分或以上;前列腺增生I-PSS评分3分或以上;前列腺体积大于20 ml。患者接受50 mg萘哌地尔，每日一次，持续4周，无应答者接受75 mg，持续4周。所有患者均进行检查，并将其数据输入给药前和给药后2天的FVC。采用改良匹兹堡睡眠质量指数（PSQI. ResultsPSQI）对患者的睡眠质量进行评价。结果睡眠质量评分为3 ~ 4分的患者分为睡眠障碍组（n = 33），睡眠质量评分<3分的患者分为无睡眠障碍组（n = 23）。服用萘哌地尔后，总I-PSS下降，焦虑评分由3.5分降至2.6分（P < 0.01）。治疗后睡眠障碍组的改良PSQI总分显著降低（16.9 ~ 14.0，P < 0.01）。萘哌地尔显着降低夜间尿量，导致在夜间多尿指数在睡眠障碍和non-disturbance groups.ConclusionThese结果表明，α1-受体阻滞剂有能力正常化睡眠障碍。无论是否存在睡眠障碍，萘哌地尔都能改善夜间多尿，这意味着它可能直接减少夜间尿量。
ObjectivesTo examine the mechanism underlying improvements in nocturia by α1-blockers, we investigated whether the α1-blocker naftopidil acts on nocturia with sleep disturbance using a frequency/volume chart (FVC).MethodsA total of 56 male patients with lower urinary tract symptoms were enrolled. The inclusion criteria were as follows: eight or more points on the I-PSS; three or more points on the I-PSS score for nocturia; and prostate volume larger than 20 ml. Patients received 50 mg of naftopidil once daily for 4 weeks, and non-responders received 75 mg for another 4 weeks. All patients were examined, and their data entered into FVC for 2 days before and after administration of naftopidil. Quality of sleep was also evaluated using modified Pittsburgh sleep quality index (PSQI).ResultsPatients with sleep quality scores of three or four were assigned to sleep disturbance group (n = 33), while those with scores of less than three were assigned to non-disturbance group (n = 23). After administration of naftopidil, total I-PSS decreased and nocturia score decreased from 3.5 to 2.6 (P < 0.01). Total mean score of modified PSQI in sleep disturbance group became significantly lower after administration of naftopidil (from 16.9 to 14.0; P < 0.01). Naftopidil significantly decreased nocturnal urine volume, resulting in a decrease in the nocturnal polyuria index in both sleep disturbance and non-disturbance groups.ConclusionThese results suggest that α1-blockers have the ability to normalize sleep disorders. Naftopidil improved nocturnal polyuria regardless of the presence of sleep disturbance, meaning that it might directly reduce nocturnal urine production.
DOI：
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发表时间：
2002
期刊：
The Journal of urology
影响因子：
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作者：
C. Hampel;P. C. Dolber;Michael P. Smith;S. Savic;Joachim W Th roff;K. Thor;D. Schwinn
通讯作者：
C. Hampel;P. C. Dolber;Michael P. Smith;S. Savic;Joachim W Th roff;K. Thor;D. Schwinn
人脊髓中的α1-肾上腺素能受体：编码α1-肾上腺素能受体亚型的mRNA在四个不同水平上的特异性局部表达。
DOI：
10.1016/s0169-328x(98)00287-3
发表时间：
1999
期刊：
Brain research. Molecular brain research
影响因子：
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作者：
Smith,MS;Schambra,UB;Wilson,KH;Page,SO;Schwinn,DA
通讯作者：
Schwinn,DA