Prodromal and residual symptoms in bipolar I disorder.
Prodromal and residual symptoms in bipolar I disorder.
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DOI：
10.1016/s0010-440x(96)90018-8
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发表时间：
1996-09
影响因子：
7.3
通讯作者：
G. Keitner;David A. Solomon;David A. Solomon;Christine E. Ryan;Christine E. Ryan;Ivan W. Miller;Ivan W. Miller;A. Mallinger;A. Mallinger;David J. Kupfer;David J. Kupfer;Ellen Frank;Ellen Frank
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文献类型：
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作者：
G. Keitner;David A. Solomon;David A. Solomon;Christine E. Ryan;Christine E. Ryan;Ivan W. Miller;Ivan W. Miller;A. Mallinger;A. Mallinger;David J. Kupfer;David J. Kupfer;Ellen Frank;Ellen Frank
目前这项研究的目的是更好地了解躁狂和抑郁的前驱症状和残留症状的性质，这是双相I型障碍患者及其家人报告的。74例双相情感障碍患者出现躁狂和抑郁的前驱症状和残留症状。在45个案例中，一名成年家庭成员提供了类似的信息。三位临床医生将这些症状分为六大类：行为、认知、情绪、神经植物人、社交和其他。临床医生还将症状分为典型症状或特殊症状。78%的患者报告了前驱抑郁症状，87%的患者报告了前驱躁狂症状；超过一半的患者报告了抑郁(54%)和躁狂(68%)的残留症状。在这四种疾病类别中，认知症状一直是患者报告的最常见症状。相当多的症状是特殊的，特别是那些报道的残留抑郁症。在两极的前驱期，患者和家属对报告的症状有很强的一致性，但在残留期则不太一致。这些初步结果表明，双相情感障碍患者及其家人可以识别前驱症状和残留症状，这些症状是相当常见的，前驱症状可能比残留症状更普遍或更容易识别。认知症状一直是患者报告的最常见的症状。
The objective of the current study was to better understand the nature of prodromal and residual symptoms of mania and depression, as reported by patients with bipolar I disorder and their family members. Prodromal and residual symptoms of mania and depression were elicited from 74 patients with bipolar 1 disorder. In 45 cases, an adult family member provided similar information. Three clinicians classified the symptoms into six broad categories: behavioral, cognitive, mood, neurovegetative, social, and other. The clinicians also categorized symptoms as typical or idiosyncratic. Seventy-eight percent of the patients reported prodromal depressive symptoms and 87% reported prodromal manic symptoms; greater than half of the patients disclosed residual symptoms of depression (54%) and mania (68%). Within each of these four illness categories, cognitive symptoms were consistently the most common symptoms reported by patients. A substantial number of symptoms were idiosyncratic, particularly those reported for residual depression. Agreement between patient and family members on reported symptoms was strong for the prodromal phase of both polarities, but less so for the residual phases. These preliminary results suggest that patients with bipolar 1 disorder and their family members can identify prodromal and residual symptoms, that these symptoms are quite common, and that prodromal symptoms may be more prevalent or easier to identify than residual symptoms. Cognitive symptoms were consistently the most common symptoms reported by patients.