Bright fluorescent nanodiamonds: No photobleaching and low cytotoxicity
Bright fluorescent nanodiamonds: No photobleaching and low cytotoxicity
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DOI：
10.1021/ja0567081
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发表时间：
2005-12-21
影响因子：
15
通讯作者：
Yu, YC
中科院分区：
文献类型：
--
作者：
Yu, SJ;Kang, MW;Yu, YC
Diamond nanocrystals emit bright fluorescence at 600−800 nm after irradiation by a 3 MeV proton beam (5 × 1015ions/cm2) and annealing at 800 °C (2 h) in vacuum. The irradiation/annealing process yields high concentrations of nitrogen-vacancy defect centers (∼107centers/μm3), making possible visualization of the individual 100 nm diamond crystallites using a fluorescence microscope. The fluorescent nanodiamonds (FND) show no sign of photobleaching and can be taken up by mammalian cells with minimal cytotoxicity. The nanomaterial can have far-reaching biological applications.
