The Drosophila position‐specific antigens are a family of cell surface glycoprotein complexes.
The Drosophila position‐specific antigens are a family of cell surface glycoprotein complexes.
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果蝇位置特异性抗原是细胞表面糖蛋白复合物家族。
DOI：
10.1002/j.1460-2075.1984.tb02131.x
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
R. White
中科院分区：
文献类型：
--
作者：
M. Wilcox;N. Brown;M. Piovant;R. J. Smith;R. White
位置特异性（PS）1和PS2单克隆抗体结合不均匀的果蝇的成熟翅成虫盘的边界分离的背侧和腹侧的发展隔间。PS1抗体优先识别背侧细胞，PS2抗体优先识别腹侧细胞。这两类抗体从成虫盘裂解物中提取不同的糖蛋白组。PS3抗体结合背侧和腹侧椎间盘细胞，并提取PS1和PS2糖蛋白集以及另外的组分。我们表明，PS抗原相关的多聚体糖蛋白复合物的细胞表面。PS3抗体识别所有复合物中存在的糖蛋白，而PS1和PS2抗体识别其自身复合物的独特组分。空间和时间的相关性表明这些分子可能在发育中起作用。
Position‐specific (PS)1 and PS2 monoclonal antibodies bind non‐uniformly to the mature wing imaginal disc of Drosophila with respect to the boundary separating the dorsal and ventral developmental compartments. PS1 antibodies preferentially recognize dorsal cells, PS2 antibodies ventral cells. Antibodies of the two classes extract distinct sets of glycoproteins from an imaginal disc lysate. PS3 antibodies bind to both dorsal and ventral disc cells and extract both PS1 and PS2 glycoprotein sets together with an additional component. We show that the PS antigens are related multimeric glycoprotein complexes on the cell surface. PS3 antibodies recognize a glycoprotein present in all complexes, while PS1 and PS2 antibodies recognize unique components of their own complexes. Spatial and temporal correlations suggest the molecules may have a function in development.