Establishing clinical remission criteria and the framework of a treat-to-target?algorithm for Takayasu arteritis: Results of a Delphi exercise carried out by an expert panel of the Japan Research Committee of the Ministry of Health, Labour and Welfare for
Establishing clinical remission criteria and the framework of a treat-to-target?algorithm for Takayasu arteritis: Results of a Delphi exercise carried out by an expert panel of the Japan Research Committee of the Ministry of Health, Labour and Welfare for
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建立高安动脉炎的临床缓解标准和目标治疗算法框架：日本厚生劳动省研究委员会专家小组进行的德尔菲演习结果
DOI：
10.1093/mr/roab081
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发表时间：
2021
影响因子：
2.2
通讯作者：
Nagafuchi Hiroko
中科院分区：
文献类型：
--
作者：
Sugihara Takahiko;Nakaoka Yoshikazu;Uchida Haruhito A;Yoshifuji Hajime;Maejima Yasuhiro;Watanabe Yoshiko;Amiya Eisuke;Tanemoto Kazuo;Miyata Tetsuro;Umezawa Natsuka;Manabe Yusuke;Ishizaki Jun;Shirai Tsuyoshi;Nagafuchi Hiroko
目的为制定缓解标准和治疗目标（T2 T）算法的建议，为Takayasu arteritis（TAK）的框架。方法日本厚生劳动省难治性血管炎研究委员会大血管炎组的研究小组由10名风湿病学家，5名心脏病学家，1名肾病学家，1名血管外科医生，1名心脏外科医生，和2名儿科风湿病学家。缓解标准项目的德尔菲调查在研究组中进行了四次循环。开发的T2 T算法，研究组进行了四个面对面的会议和两轮的德尔菲连同3 patients.ResultsInitial文献回顾导致在一个列表中的117个候选项目缓解标准，其中56个项目的平均得分≥4（0-5）被提取，包括疾病活动领域和治疗/合并症领域。研究组提供了六个总体原则的T2 T算法，两个建议的治疗目标，五个评价疾病活动和成像结果，包括正电子发射断层扫描计算机断层扫描，和两个治疗intensify.ConclusionsWe开发了一个T2 T算法和建议的标准化缓解标准的德尔菲练习。这些将指导未来对不同TAK治疗方案的评价。
ObjectivesTo develop a proposal for remission criteria and a framework for a treat-to-target (T2T) algorithm for Takayasu arteritis (TAK).MethodsA study group of the large-vessel vasculitis group of the Japanese Research Committee of the Ministry of Health, Labour and Welfare for Intractable Vasculitis consists of 10 rheumatologists, 5 cardiologists, 1 nephrologist, 1 vascular surgeon, 1 cardiac surgeon, and 2 paediatric rheumatologists. A Delphi survey of remission criteria items was circulated among the study group over four reiterations. To develop the T2T algorithm, the study group conducted four face-to-face meetings and two rounds of Delphi together with three patients.ResultsInitial literature review resulted in a list of 117 candidate items for remission criteria, of which 56 items with a mean score of ≥4 (0–5) were extracted including disease activity domains and treatment/comorbidity domains. The study group provided six overarching principles for the T2T algorithm, two recommendations on treatment goals, five on evaluation of disease activity and imaging findings including positron emission tomography–computed tomography, and two on treatment intensification.ConclusionsWe developed a T2T algorithm and proposals for standardised remission criteria by means of a Delphi exercise. These will guide future evaluation of different TAK treatment regimens.