Levels of endothelial cell stimulating angiogenesis factor and vascular endothelial growth factor are elevated in psoriasis
Levels of endothelial cell stimulating angiogenesis factor and vascular endothelial growth factor are elevated in psoriasis
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DOI：
10.1046/j.1365-2133.1999.03205.x
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发表时间：
1999-12-01
影响因子：
10.3
通讯作者：
Griffiths, CEM
中科院分区：
文献类型：
--
作者：
Bhushan, M;McLaughlin, B;Griffiths, CEM
新生血管似乎在银屑病斑块的演变中起着早期和重要的作用。我们研究了两个已知的血管生成因子，内皮细胞刺激血管生成因子（ESAF）和血管内皮生长因子（VEGF），在慢性斑块状银屑病患者和正常对照组的皮肤中的分布和生产。结果表明，银屑病患者皮损中ESAF和VEGF的表达均显著高于正常对照组（P = 0.006和P < 0.0001），银屑病患者皮损中ESAF和VEGF的表达也显著高于正常对照组（P = 0.001和P < 0.0001）。银屑病斑块中ESAF和VEGF的组织水平与银屑病的临床严重程度密切相关（分别为I = 0.6和r = 0.9）。银屑病患者血清ESAF和VEGF水平显著高于对照组（分别为P = 0.001和P = 0.02）。体外培养研究表明，ESAF是由角质形成细胞和成纤维细胞在正常皮肤中以大约相等的量产生的，而VEGF主要由角质形成细胞分泌。在银屑病患者的受累和未受累皮肤中观察到类似的模式。但与正常对照皮肤相比，受累皮肤和非受累皮肤的角质形成细胞和成纤维细胞分泌的两种因子均增加（P < 0.001）。银屑病斑块中已知促进新血管形成的两种分子ESAF和VEGF的水平和分泌增加，表明它们在这种疾病中的致病作用。
Neovascularization appears to play an early and important part in the evolution of psoriatic plaques. We studied the distribution and production of two known angiogenesis factors, endothelial cell stimulating angiogenesis factor (ESAF) and vascular endothelial growth factor (VEGF), in the skin of patients with chronic plaque psoriasis and normal control subjects. Our results showed that tissue levels of ESAF and VEGF were significantly elevated in involved as compared with normal control skin (P = 0.006 and P < 0.0001, respectively), Tissue levels of ESAF and VEGF were also raised in involved skin as compared with uninvolved skin in patients with psoriasis (P = 0.001 and P < 0.0001, respectively). Tissue levels of ESAF and VEGF in plaques of psoriasis correlated closely with the clinical severity of psoriasis (I = 0.6 and r = 0.9, respectively). Serum levels of ESAF and VEGF were significantly raised in patients with psoriasis as compared with control subjects (P = 0.001 and P = 0.02, respectively). In vitro culture studies revealed that ESAF is produced by both keratinocytes and fibroblasts in approximately equal quantities in normal skin, whereas VEGF is secreted predominately by keratinocytes. A similar pattern is seen in both involved and uninvolved skin of patients with psoriasis. However, there is increased secretion of both factors in keratinocytes and fibroblasts from involved and uninvolved skin as compared with normal control skin (P < 0.001). The increased levels and secretion in plaques of psoriasis of two molecules, ESAF and VEGF, known to promote new blood vessel formation, suggest a pathogenetic role for them in this disease.