Hydrogen sulfide: a gasotransmitter of clinical relevance.
Hydrogen sulfide: a gasotransmitter of clinical relevance.
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DOI：
10.1007/s00109-012-0873-4
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发表时间：
2012-03
影响因子：
4.7
通讯作者：
Snyder, Solomon H.
中科院分区：
文献类型：
--
作者：
Vandiver, M. Scott;Snyder, Solomon H.
虽然H2S在生物组织中的存在已经被发现超过300年，但它是最近才被认识到的作为生理信使分子的气体递质。长期以来，人们一直认为胱硫醚γ-裂解酶（CSE）和胱硫醚β-合成酶（CBS）是产生H2S的酶，这些酶的抑制剂已被用于表征H2S对各种器官的影响。H2S是一种生理调节剂的有力证据伴随着具有CSE和CBS靶向缺失的小鼠的发育而来。最佳表征的是由CSE形成的H2S作为内皮衍生的舒张因子的作用，其通常通过ATP敏感性钾通道起作用来调节血压。H2S参与炎症过程的各个阶段，主要发挥抗炎作用。目前，开发治疗剂的最先进的努力涉及H2S供体与非甾体抗炎药（NSAID）的组合。H2S部分对通常受NSAID不利影响的胃粘膜提供细胞保护，而H2S和前列腺素合成抑制的组合可提供协同抗炎作用。
Though the existence of H2S in biological tissues has been known for over 300 years, it is the most recently appreciated of the gasotransmitters as a physiologic messenger molecule. The enzymes cystathionine γ-lyase (CSE) and cystathionine β-synthase (CBS) had long been speculated to generate H2S, and inhibitors of these enzymes had been employed to characterize influences of H2S in various organs. Definitive evidence that H2S is a physiologic regulator came with the development of mice with targeted deletion of CSE and CBS. Best characterized is the role of H2S, formed by CSE, as an endothelial derived relaxing factor that normally regulates blood pressure by acting through ATP-sensitive potassium channels. H2S participates in various phases of the inflammatory process, predominantly exerting anti-inflammatory actions. Currently, the most advanced efforts to develop therapeutic agents involve the combination of H2S donors with non-steroidal anti-inflammatory drugs (NSAIDs). The H2S moiety provides cytoprotection to gastric mucosa normally adversely affected by NSAIDs, while the combination of H2S and inhibition of prostaglandin synthesis may afford synergistic anti-inflammatory influences.
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影响因子：
20.1
作者：
Ishikawa, M;Kajimura, M;Suematsu, M
通讯作者：
Suematsu, M
DOI：
10.1073/pnas.0705891104
发表时间：
2007-09-25
影响因子：
11.1
作者：
Elrod, John W.;Calvert, John W.;Lefer, David J.
通讯作者：
Lefer, David J.
DOI：
10.1073/pnas.87.2.682
发表时间：
1990-01-01
影响因子：
11.1
作者：
BREDT, DS;SNYDER, SH
通讯作者：
SNYDER, SH
DOI：
10.1073/pnas.97.17.9747
发表时间：
2000-08-15
影响因子：
11.1
作者：
Brandes, RP;Schmitz-Winnenthal, FH;Busse, R
通讯作者：
Busse, R
影响因子：
4.8
作者：
Boehning, D;Sedaghat, L;Snyder, SH
通讯作者：
Snyder, SH