Comparison of cognitive performance among different age groups in patients with obstructive sleep apnea
Comparison of cognitive performance among different age groups in patients with obstructive sleep apnea
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DOI：
10.1007/s11325-007-0133-y
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发表时间：
2008-02-01
影响因子：
2.5
通讯作者：
Roussos, Charis
中科院分区：
文献类型：
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作者：
Alchanatis, Manos;Zias, Nikolaos;Roussos, Charis
本研究旨在探讨阻塞性睡眠呼吸暂停综合征对中青年患者认知功能的影响。将患者分为两组，一组为50岁以下患者30例，另一组为50岁以上患者28例。正常受试者同样被分成两组，由17名年轻人和24名老年对照组组成。患者和对照组接受了通宵多导睡眠图检查，随后通过注意力警觉性测试进行了认知测试。比较年轻和中年患者，认知表现有统计学意义上的差异，特别是在注意力测试中。年轻患者的认知表现与年龄匹配的对照组相似，而中年患者的认知能力与年龄匹配的对照组相比有所下降。虽然我们只研究了两个年龄组，以50岁为分界点，但我们可以证明，未经治疗的睡眠呼吸暂停患者的认知恶化是年龄相关的，几个因素可能会导致这种影响，包括脑缺氧、睡眠碎片或合并疾病。患有睡眠呼吸暂停的老年患者表现出认知能力下降，而病情严重程度相同的年轻患者能够(以某种方式)弥补这一影响。
The aim of this study was to evaluate the effect of obstructive sleep apnea syndrome on the cognitive performance of young and middle-aged patients. Patients were divided into two groups, one consisting of 30 patients less than 50 years of age and the other consisting of 28 patients 50 years and over. Normal subjects were similarly divided into two groups, composed of 17 younger and 24 older controls. Patients and controls were examined with all-night polysomnography and subsequently underwent cognitive testing via attention-alertness tests. Comparing young to middle-aged patients, there were statistically significant differences in cognitive performance, especially in attention tests. Younger patients' cognitive performance was similar to their age-matched controls, while middle-aged patients showed cognitive decline in comparison with their age-matched controls. Although we studied only two age groups using 50 years of age as a cut-off, we could demonstrate that cognitive deterioration of untreated sleep apnea patients is age dependent, and several factors may contribute to this effect including brain hypoxia, sleep fragmentation, or comorbidities. Aging patients with sleep apnea demonstrate cognitive decline, while younger patients with the same disease severity are (somehow) able to compensate for this effect.