Regulatory T cell-mediated suppression: potential role of ICER
Regulatory T cell-mediated suppression: potential role of ICER
复制标题
DOI：
10.1189/jlb.0706474
复制
发表时间：
2007-01-01
影响因子：
5.5
通讯作者：
Sakaguchi, Shimon
中科院分区：
文献类型：
--
作者：
Bodor, Josef;Fehervari, Zoltan;Sakaguchi, Shimon
调节性T细胞（T- r）如何抑制T细胞反应尚不清楚。已经提出了多种作用模式，包括细胞接触依赖和/或细胞因子依赖的机制。抑制可能涉及到TR细胞和应答T细胞之间的直接接触。或者，TR细胞可能通过调节共刺激，诱导抑制性细胞因子的分泌或色氨酸代谢的增加，作用于树突状细胞，降低树突状细胞诱导T细胞的能力。在这里，我们回顾了接触依赖的、tr介导的CD25(-) T淋巴细胞中IL-2产生抑制的新机制，以及诱导型cAMP早期抑制因子（ICER）在这种抑制中的潜在作用。最后，由TR细胞或其他细胞产生的tgf - β和IL-10等细胞因子可能会施加局部抑制，这种抑制可以通过与接触依赖性TR介导的抑制类似的基本机制来传递。
How regulatory T (T-R) cells dampen T cell responses remains unclear. Multiple modes of action have been proposed, including cell contact-dependent and/or cytokine-dependeut mechanisms. Suppression may involve direct contact between TR cells and responder T cells. Alternatively, TR cells may act on dendritic cells to reduce their ability to prime T cells by modulating costimulation, inducing the secretion of suppressive cytokines or the increase of tryptophan metabolism. Here, we review emerging, novel mechanisms involved in contact-dependent, TR-mediated suppression of IL-2 production in responder CD25(-) T lymphocytes and the potential involvement of inducible cAMP early repressor (ICER) in this suppression. Finally, cytokines such as TGF-beta and IL-10, produced by TR cells or other cells, may exert local suppression, which can be conveyed by basic mechanism(s) acting in a similar manner as contact-dependent, TR-mediated suppression.