aPKC in neuronal differentiation, maturation and function.
aPKC in neuronal differentiation, maturation and function.
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DOI：
10.1042/ns20190019
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发表时间：
2019-09-01
影响因子：
--
通讯作者：
Ghosh, Sourav
中科院分区：
文献类型：
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作者：
Hapak, Sophie M;Rothlin, Carla V;Ghosh, Sourav
非典型蛋白激酶C（aPKC）-PRKCI、PRKCZ和PKMzeta-形成蛋白激酶C（PKC）家族内的亚家族。这些激酶在神经系统中表达，包括在其发育期间和成年期。其中一种aPKC，PKMzeta，似乎仅限于神经系统。已知aPKC在多种细胞应答中发挥作用，例如增殖、分化、极性、迁移、存活和关键代谢功能，例如葡萄糖摄取，其对于神经系统发育和功能至关重要。因此，这些激酶在神经系统中的功能作用引起了人们的极大兴趣。本文就aPKCs在神经发育、神经成熟和功能中的表达和作用作一综述。尽管基因缺失与基因沉默方法的研究结果看似矛盾，但我们认为aPKCs可能是调节许多重要神经发育和神经元功能的候选者，并可能与许多人类神经精神疾病相关。
The atypical Protein Kinase Cs (aPKCs)-PRKCI, PRKCZ and PKMzeta-form a subfamily within the Protein Kinase C (PKC) family. These kinases are expressed in the nervous system, including during its development and in adulthood. One of the aPKCs, PKMzeta, appears to be restricted to the nervous system. aPKCs are known to play a role in a variety of cellular responses such as proliferation, differentiation, polarity, migration, survival and key metabolic functions such as glucose uptake, that are critical for nervous system development and function. Therefore, these kinases have garnered a lot of interest in terms of their functional role in the nervous system. Here we review the expression and function of aPKCs in neural development and in neuronal maturation and function. Despite seemingly paradoxical findings with genetic deletion versus gene silencing approaches, we posit that aPKCs are likely candidates for regulating many important neurodevelopmental and neuronal functions, and may be associated with a number of human neuropsychiatric diseases.