Estrogen attenuates HSP 72 expression in acutely exercised male rodents
Estrogen attenuates HSP 72 expression in acutely exercised male rodents
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DOI：
10.1007/s004210050579
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发表时间：
1999-08-01
期刊：
影响因子：
--
通讯作者：
Noble, EG
中科院分区：
文献类型：
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作者：
Paroo, Z;Tiidus, PM;Noble, EG
雌激素已被证明可以减少运动后骨骼肌的损伤。运动引起的肌肉损伤可能是运动后热休克蛋白（HSPs）表达升高的一个因素。因此，本研究旨在探讨雌激素对雄性和雌性啮齿动物运动后HSP 72和热休克同源物HSC 73水平的影响。在剧烈的跑步机运动之前。雄性和雌性Sprague-Dawley大鼠每天接受40 μ（-1）β-雌二醇3-苯甲酸酯或橄榄油载体的注射，持续2周。与注射溶剂的对照组相比，雌二醇治疗组雄性动物的心、肝、肺、股红肌和股白色肌中运动后HSP 72含量降低2 - 4倍（P <0.05）。与男性相比，女性有显着降低运动后HSP 72水平，这是不受雌二醇补充。此外，雌二醇管理雄性啮齿动物导致HSP反应类似于女性运动后。因此，本研究的结果表明，雌激素是运动后HSP 72水平在男性和女性之间观察到的差异的因素。
Estrogen has been shown to reduce post-exercise skeletal muscle damage. Exercise-induced muscle damage maybe a factor in the elevated post-exercise expression of heat-shock proteins (HSPs). Thus, the present investigation was conducted in order to examine the influence of estrogen on post-exercise levels of HSP 72 and heat-shock cognate, HSC 73, in male and female rodents. Prior to an acute bout of treadmill. running, male and female Sprague-Dawley rats received daily injections of either 40 mu g.kg(-1) of beta-estradiol 3-benzoate or olive oil vehicle for 2 weeks. A two- to fourfold reduction in post-exercise HSP 72 content was observed in the heart, liver, lung and red and white vastus muscles of estradiol-treated males compared with their vehicle-injected counterparts (P < 0.05). Compared to the males, the females had significantly lower post-exercise HSP 72 levels which were not affected by estradiol supplementation. Moreover, estradiol administration in male rodents resulted in a HSP response similar to that of females following exercise. Thus, the results of the present investigation suggest that estrogen is the factor responsible for the observed differences in post-exercise HSP 72 levels between males and females.