CD8+T lymphocytes protect SCID mice against Encephalitozoon cuniculi infection
CD8+T lymphocytes protect SCID mice against Encephalitozoon cuniculi infection
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DOI：
10.1016/s0020-7519(01)00134-5
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发表时间：
2001-05-15
影响因子：
4
通讯作者：
Kopecky, J
中科院分区：
文献类型：
--
作者：
Braunfuchsová, P;Salát, J;Kopecky, J
微孢子虫是专性细胞内寄生虫，可引起免疫功能低下患者的机会性感染。两种主要的T细胞亚群在抗微孢子虫免疫中的作用已经用兔脑虫-严重联合免疫缺陷（SCID）小鼠模型进行了研究。虽然用CD4 + T淋巴细胞缺失的初始BALB/c脾细胞重建的SCID小鼠可以解决感染，但过继性转移CD8 + T细胞缺失的脾细胞不能保护动物免受致命的膀胱绦虫感染。在短期cr -51释放试验中，E， cucuulii免疫小鼠的脾细胞特异性杀死了同基因感染的巨噬细胞。这些结果提示细胞毒性T淋巴细胞在保护机体免受棘球绦虫感染中的重要作用。(C) 2001澳大利亚寄生虫学学会Elsevier Science Ltd.出版。版权所有。
Microsporidia are obligate intracellular parasites that cause opportunistic infections in immunocompromised patients. The role of two main T cell subsets in anti-microsporidial immunity has been studied using an Encephalitozoon cuniculi-severe combined immunodeficient (SCID) mouse model. Whereas SCID mice reconstituted with CD4 + T lymphocyte-depleted naive BALB/c splenocytes resolved the infection, adoptive transfer of CD8 + T cell-depleted splenocytes failed to protect the animals against a lethal E. cuniculi infection. Splenocytes from E, cuniculi-immune mice specifically killed syngeneic infected macrophages in a short-term Cr-51-release assay. These results suggest the crucial role of cytotoxic T lymphocytes in the protection against E. cuniculi infection. (C) 2001 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.