Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial.
Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial.
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DOI：
10.1093/ajcn/79.4.544
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发表时间：
2004-04
期刊：
影响因子：
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通讯作者：
B. Nicklas;W. Ambrosius;S. Messier;G. Miller;B. Penninx;R. Loeser;S. Palla;E. Bleecker;M. Pahor
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文献类型：
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作者：
B. Nicklas;W. Ambrosius;S. Messier;G. Miller;B. Penninx;R. Loeser;S. Palla;E. Bleecker;M. Pahor
背景技术持续性低度炎症是多种慢性疾病和全因死亡率的独立预测因素。目的本研究的目的是确定饮食诱导的减肥和运动对慢性炎症标志物的独立和综合影响。设计 316 名居住在社区、年龄较大（> 或 = 60 岁）、超重或肥胖 [体重指数（以 kg/m2）> 或 = 28]、久坐、有膝骨关节炎影像学证据的男性和女性被随机分配接受 4 项为期 18 个月的治疗：健康生活方式控制、饮食诱导减肥、运动和饮食加运动。运动干预包括重量训练和步行 1 小时，每周 3 次。减肥干预措施包括每周与注册营养师进行一次会议，以提供降低能量摄入的教育和支持。结果 与没有减肥治疗相比，饮食诱导的减肥干预导致 C 反应蛋白 (P = 0.01)、白细胞介素 6 (P = 0.009) 和可溶性肿瘤坏死因子 α 受体 1 (P = 0.007) 浓度的显着降低。可溶性肿瘤坏死因子 α 受体 1 的变化与体重变化相关，但 C 反应蛋白或白细胞介素 6 的变化不相关。运动训练对这些炎症生物标志物没有显着影响，减肥和运动训练之间没有显着的相互作用。结论 这些发现提供了来自随机对照试验的证据，表明旨在减轻体重的饮食干预可减少老年肥胖者的整体炎症。需要进行更多研究来评估不同运动方式和强度对炎症的影响。
BACKGROUND Persistent, low-grade inflammation is an independent predictor of several chronic diseases and all-cause mortality. OBJECTIVE The intention of this study was to determine the independent and combined effects of diet-induced weight loss and exercise on markers of chronic inflammation. DESIGN Three hundred sixteen community-dwelling, older (> or = 60 y), overweight or obese [body mass index (in kg/m2) > or = 28], sedentary men and women with radiographic evidence of knee osteoarthritis were randomly assigned to four 18-mo treatments: healthy lifestyle control, diet-induced weight loss, exercise, and diet plus exercise. The exercise intervention consisted of combined weight training and walking for 1 h 3 times/wk. The weight-loss intervention consisted of a weekly session with a registered dietitian to provide education and support for lowering energy intake. RESULTS The diet-induced weight-loss intervention resulted in significantly greater reductions in concentrations of C-reactive protein (P = 0.01), interleukin 6 (P = 0.009), and soluble tumor necrosis factor alpha receptor 1 (P = 0.007) than did no weight-loss treatment. Changes in soluble tumor necrosis factor alpha receptor 1 but not in C-reactive protein or interleukin 6 correlated with changes in body weight. Exercise training did not have a significant effect on these inflammatory biomarkers, and there was no significant interaction between weight loss and exercise training. CONCLUSIONS These findings provide evidence from a randomized controlled trial that a dietary intervention designed to elicit weight loss reduces overall inflammation in older, obese persons. Additional studies are needed to assess the effects of different modes and intensities of exercise on inflammation.