Rational Synthesis of Magnetic Thermosensitive Microcontainers as Targeting Drug Carriers
Rational Synthesis of Magnetic Thermosensitive Microcontainers as Targeting Drug Carriers
复制标题
合理合成磁性热敏微容器作为靶向药物载体
DOI：
10.1002/smll.200801154
复制
发表时间：
2009-03-06
期刊：
影响因子：
13.3
通讯作者：
Wang, Chang-Chun
中科院分区：
文献类型：
--
作者：
Chen, Li-Bo;Zhang, Feng;Wang, Chang-Chun
提出了一种制备具有聚（N-异丙基丙烯酰胺）壁的Fe_3O_4纳米颗粒磁性温敏微容器的新方法，该微容器经历了温度诱导的体积相变并呈现出令人印象深刻的磁响应。微容器具有明确的结构，具有窄的尺寸分布。微容器的壁厚可根据需要进行控制。与其他制备方法相比，该方法简单且可重复。这些微容器的磁饱和度足够高，以满足大多数生物应用的要求。为了进一步研究这些微容器的潜在应用，将它们作为药物载体进行测试，并仔细研究药物的装载和释放过程。药物包封率和载体中的药物含量是pH依赖性的，并且载体在碱性条件下具有约50wt%的最大载药量。药物从微容器中的释放可以通过环境pH、温度和磁力来控制。
A new approach to the fabrication of magnetic thermosensitive microcontainers of Fe3O4 nanoparticles with poly(N-isopropylacrylamide) walls is presented, The microcontainers undergo a temperature-induced volume phase transition and present an impressive magnetic response. The microcontainers have a well-defined structure with a narrow size distribution. The wall thicknesses of the microcontainers can be controlled according to requirements. Compared to other preparation methods., the process is simple and reproducible. The magnetic saturation of these microcontainers is high enough to meet most requirements of bioapplications. To further investigate the potential application of these microcontainers, they are tested as drug carriers, with the drug loading and releasing processes carefully studied. The drug encapsulation efficiency and drug content in the carriers are pH-dependent, and the carriers have a maximal drug loading of about 50 wt% under alkaline conditions. The release of the drug from the microcontainers can be controlled by the environmental pH, temperature, and magnetic force.