Chitosan based hydrogel microspheres as drug carriers
Chitosan based hydrogel microspheres as drug carriers
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DOI：
10.1002/mabi.200600290
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发表时间：
2007-05-10
影响因子：
4.6
通讯作者：
Bakos, Dusan
中科院分区：
文献类型：
--
作者：
Vodna, Lucia;Bubenikova, Silvia;Bakos, Dusan
采用聚电解质络合法制备了壳聚糖/三聚磷酸盐(CHIT/TPP)和壳聚糖/三聚磷酸盐/硫酸软骨素(CHIT/TPP/CHS)核壳型微球，以期开发一种生物相容性的药物载体。采用无菌条件下多循环反应器连续法制备微球。所制得的微球均为球形，具有多孔结构。CHS作为第二聚阴离子的存在，提高了微球的机械阻力，从而增韧了微球的壳层结构。将氟喹诺酮类抗生素氧氟沙星(OFL)溶解于壳聚糖溶液中，形成络合物，对微球的制备工艺进行了改进。本研究显示了CHIT/TPP微球与CHIT/TPP/CHS微球在OR释放方面的差异，并暗示了控制这一过程的可能性。
Chitosan/tripolyphosphate (CHIT/TPP) and chitosan/tripolyplaosphate/chondroitin sulfate (CHIT/TPP/CHS) core-shell type microspheres were prepared by polyelectrolyte complexation in order to develop a biocompatible matrix for drug delivery. The continual method using a multi-loop reactor under sterile conditions was applied for microsphere preparation. All the types of microspheres produced were spherical in shape and had a porous structure. The mechanical resistance of the microspheres increased in the presence of CHS as the second polyanion, which toughened the microsphere shell structure. For a drug release application, the process of microsphere preparation was modified by dissolving ofloxacin (OFL), the fluoroquinolone antibiotic, in CHIT solution before complex formation. This study shows the difference in OR release comparing the microspheres CHIT/TPP and CHIT/TPP/CHS and implies the potential to control this process.