Marital disruption is associated with shorter salivary telomere length in a probability sample of older adults.
Marital disruption is associated with shorter salivary telomere length in a probability sample of older adults.
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DOI：
10.1016/j.socscimed.2016.03.029
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Sbarra DA
中科院分区：
文献类型：
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作者：
Whisman MA;Robustelli BL;Sbarra DA
婚姻破裂(即婚姻分居、离婚)与一系列不良的心理和身体健康结果有关，包括增加全因死亡的风险。一个可能有助于解释婚姻破裂和健康状况不佳之间联系的生物学中介是细胞衰老加速。这项研究调查了美国≥50岁成年人的概率样本中婚姻破裂和唾液端粒长度之间的关系。参与者是参与2008年健康与退休研究浪潮的3526人。采用实时定量聚合酶链式反应(QPCR)对唾液DNA进行端粒长度分析。健康和生活方式因素，创伤和应激生活事件，以及神经质通过自我报告进行评估。线性回归分析被用来检验预测变量和唾液端粒长度之间的关系。根据他们2006年的婚姻状况数据，分居或离婚的人的唾液端粒比连续结婚或从未结婚的人短，婚姻破裂与唾液端粒长度之间的关联不受性别或神经质的影响。此外，在调整了人口统计和社会经济变量、神经质、吸烟、体重、创伤性生活事件和其他应激性生活事件后，婚姻破裂和唾液端粒长度之间的关联在统计上仍然显著。此外，结果显示，有离婚史的已婚成年人的唾液端粒比那些连续结婚或从未结婚的人更短。以端粒缩短为指标的细胞老化加速，可能是婚姻破裂与发病率和死亡率相关的一条途径。
Marital disruption (i.e., marital separation, divorce) is associated with a wide range of poor mental and physical health outcomes, including increased risk for all-cause mortality. One biological intermediary that may help explain the association between marital disruption and poor health is accelerated cellular aging. This study examines the association between marital disruption and salivary telomere length in a United States probability sample of adults ≥ 50 years of age. Participants were 3,526 individuals who participated in the 2008 wave of the Health and Retirement Study. Telomere length assays were performed using quantitative real-time polymerase chain reaction (qPCR) on DNA extracted from saliva samples. Health and lifestyle factors, traumatic and stressful life events, and neuroticism were assessed via self-report. Linear regression analyses were conducted to examine the associations between predictor variables and salivary telomere length. Based on their marital status data in the 2006 wave, people who were separated or divorced had shorter salivary telomeres than people who were continuously married or had never been married, and the association between marital disruption and salivary telomere length was not moderated by gender or neuroticism. Furthermore, the association between marital disruption and salivary telomere length remained statistically significant after adjusting for demographic and socioeconomic variables, neuroticism, cigarette use, body mass, traumatic life events, and other stressful life events. Additionally, results revealed that currently married adults with a history of divorce evidenced shorter salivary telomeres than people who were continuously married or never married. Accelerated cellular aging, as indexed by telomere shortening, may be one pathway through which marital disruption is associated with morbidity and mortality.