Insulin and insulin-like growth factors/somatomedins in fetal and neonatal development.
Insulin and insulin-like growth factors/somatomedins in fetal and neonatal development.
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胎儿和新生儿发育中的胰岛素和胰岛素样生长因子/生长调节素。
DOI：
10.1016/s0300-595x(84)80009-2
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
D'Ercole,AJ
中科院分区：
文献类型：
--
作者：
Underwood,LE;D'Ercole,AJ
在这篇报告中，我们试图回顾关于胎儿和新生儿生长的激素调节的知识现状，并特别强调胰岛素和生长抑素在胎儿生长中的作用。由于无法接触到胎儿，对其发育的研究受到身体和伦理上的限制，导致进展缓慢。此外，胎儿有机会从各种来源的同源激素中受益，这使得很难评估单个激素停用的效果。许多进展是由于试图确定胎儿血液中的激素浓度，确定胎儿组织与激素的结合，以及检查自然或实验导致的激素可获得性偏差的影响。在未来，应该把注意力集中在开发研究模型上，以便更好地将胎儿从多种同源激素的影响中分离出来。更详细地研究个体生长因子对胎儿细胞和组织体外生长的影响，评估胎儿生长因子的控制机制，以及旨在认识个体生长因子之间以及生长因子与激素之间复杂相互作用的实验，也应该取得进展。
In this presentation we have attempted to review the status of knowledge of the hormonal regulation of fetal and neonatal growth, and have placed particular emphasis on the roles of insulin and somatomedin in fetal growth. The inaccessibility of the fetus and the physical and ethical constraints on study of its growth have resulted in slow progress. Furthermore, the opportunity for the fetus to benefit from homologous hormones from a variety of sources has made it difficult to assess the effect of withdrawal of individual hormones. Many of the advances made have resulted from attempts to determine hormone concentrations in fetal blood, identify hormone binding by fetal tissues, and examine the effects of natural or experimentally induced deviations in hormone availability. In the future, attention should be focused on developing study models which better isolate the fetus from the influence of multiple, homologous hormones. Progress should also come as the result of more detailed study of the influence of individual growth factors on in vitro growth of fetal cells and tissues, assessment of control mechanisms for growth factors in the fetus, and experiments directed at recognizing the complex interactions between individual growth factors and between growth factors and hormones.