Stimuli-responsive polypeptide vesicles by conformation-specific assembly
Stimuli-responsive polypeptide vesicles by conformation-specific assembly
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DOI：
10.1038/nmat1093
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发表时间：
2004-04-01
期刊：
影响因子：
41.2
通讯作者：
Deming, TJ
中科院分区：
文献类型：
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作者：
Bellomo, EG;Wyrsta, MD;Deming, TJ
在生物学中，脂质以其组装成球形囊泡的能力而闻名（1）。蛋白质，特别是病毒衣壳，也可以形成规则的囊泡样结构，其中许多相同亚基的精确折叠和稳定构象指导它们的自组装（2）。存在于这些亚基上的功能性也控制它们在细胞环境中的分解，例如，响应于pH变化（3）。在这里，我们报告的制备二嵌段共聚肽，自组装成球形囊泡组件的大小和结构主要是由有序的构象的聚合物片段，以类似的方式病毒衣壳组装。此外，将功能性并入这些分子中以使它们对环境刺激敏感，这对于药物递送应用是期望的。在这些系统中展示的组装和功能的控制是对合成可以模拟蛋白质中发现的精确三维组装的材料的重大进展。
In biology, lipids are well known for their ability to assemble into spherical vesicles(1). Proteins, in particular virus capsids, can also form regular vesicle-like structures, where the precise folding and stable conformations of many identical subunits directs their self-assembly(2). Functionality present on these subunits also controls their disassembly within the cellular environment, for example, in response to a pH change(3). Here, we report the preparation of diblock copolypeptides that self-assemble into spherical vesicular assemblies whose size and structure are dictated primarily by the ordered conformations of the polymer segments, in a manner similar to viral capsid assembly. Furthermore, functionality was incorporated into these molecules to render them susceptible to environmental stimuli, which is desirable for drug-delivery applications. The control of assembly and function exhibited in these systems is a significant advance towards the synthesis of materials that can mimic the precise three-dimensional assembly found in proteins.