Preparation and characterization of microspheres based on blend of poly(lactic acid) and poly(ε-caprolactone) with poly(vinyl alcohol) as emulsifier
Preparation and characterization of microspheres based on blend of poly(lactic acid) and poly(ε-caprolactone) with poly(vinyl alcohol) as emulsifier
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DOI：
10.1016/j.arabjc.2010.08.003
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发表时间：
2012-01-01
影响因子：
6
通讯作者：
Soegiyono, Bambang
中科院分区：
文献类型：
--
作者：
Kemala, Tetty;Budianto, Emil;Soegiyono, Bambang
本文采用水包油(o/w)乳液溶剂蒸发法制备微球。采用一定组成和特性的聚乳酸（PLA）和聚己内酯（PCL）共混物等可生物降解聚合物，以聚乙烯醇（PVA）为乳化剂制备微球。本研究观察了不同浓度 PVA（1%、1.5%、2% 和 2.5% PVA）下微球颗粒的尺寸分布。还观察了过程中 PVA 体积变化的影响（50、100、150、200 和 250 mL）。 PLA 和 PCL 的共混物仅通过它们之间的物理相互作用形成。这可以从显示 PLA 和 PCL 成分的 FTIR 光谱中看出。通过光学显微镜（MO）观察微球的物理尺寸和外观。本研究的总体结果表明，使用50-150 mL 2.5%聚乙烯醇的配方产生的微球具有最均匀的尺寸分布。 (C) 2010 年沙特国王大学。由 Elsevier B.V. 制作和托管。保留所有权利。
In this paper, microspheres were prepared by oil-in-water (o/w) emulsion solvent evaporation method. Biodegradable polymer such as blend of poly (lactic acid) (PLA) and poly(e-caprolactone) (PCL) with certain compositions and characteristics was used to prepare the microspheres with poly(vinyl alcohol) (PVA) as an emulsifier. This study observed the microspheres particle's size distribution at various concentrations of PVA (1%, 1.5%, 2%, and 2.5% PVA). The PVA volume variations effects during the process (50, 100, 150, 200, and 250 mL) were also observed. The blend of PLA and PCL is formed only by physical interaction between them. This can be seen from the FTIR spectrum which shows both PLA and PCL component. The microspheres physical size and appearance were observed by optical microscope (MO). The overall results of this study showed that the formula which used 50-150 mL of 2.5% polyvinyl alcohol produced the microspheres with the most uniform size distribution. (C) 2010 King Saud University. Production and hosting by Elsevier B.V. All rights reserved.