Relationship of serotype, leukotoxin gene type and lysogeny in Actinobacillus actinomycetemcomitans to periodontal disease status.
Relationship of serotype, leukotoxin gene type and lysogeny in Actinobacillus actinomycetemcomitans to periodontal disease status.
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伴放线放线杆菌血清型、白细胞毒素基因类型和溶原性与牙周病状态的关系。
DOI：
10.1111/j.1600-0722.1997.tb00246.x
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Preus,H
中科院分区：
文献类型：
--
作者：
BarrettoTinoco,EM;Stevens,R;Haubek,D;Lai,CH;Balachandran,S;Preus,H
伴放线放线杆菌与不同形式的牙周病有关，特别是局部幼年性牙周炎（LJP）。该细菌具有多种毒力因子，已被证明与宿主免疫系统相互作用。在这些因素中，白细胞毒素、表面抗原（血清型）和噬菌体被认为直接或间接影响感染过程。然而，很少有研究能够单独或联合证明这些因素与牙周病之间的关联。因此，本研究的目的是调查牙周病状态与选定的毒力因子（血清型、噬菌体的存在以及白细胞毒素基因启动子区是否存在 530 bp 缺失）之间可能的相关性。 36 名受试者参与了这项研究。血清型 c 是牙周受影响受试者中最常见的血清型，尽管也存在血清型 a 和 b，但 36 个菌株中有 27 个含有噬菌体，并且有强有力的证据表明某些噬菌体与之前表征的 ΦAa 噬菌体不同。放线菌伴随 F 片段噬菌体更常与牙周病相关。 5 个菌株，均为血清型 b，其中 3 个来自 LJP 患者，2 个来自健康受试者，在白细胞毒素基因的启动子区域显示 530 bp 缺失。
Actinobacillus actinomycetemcomitans has been associated with different forms of periodontities, particularly with localized juvenile periodontitis (LJP). The bacterium possesses several virulence factors which have been shown to interact with the hos immune system. Among these factors, leukotoxin, surface antigens (serotype) and bacteriophages have been suggested directly or indirectly to influence the course of infection. However, few studies have been able to show associations between these factors and periodontal disease, alonw or in combination. Thus, the purpose of the present study was to investigate possible correlations between periodontal disease status and selected virulence factors (serotype, presence of bacteriophages, and the presence of a 530 bp delection in the promotor region of the leukotoxin gene). 36 subjects took part in the study. Serotype c was the most frequently found serotype among periodontally affected subjects, although serotypes a and b were also present, 27 out of 36 strains harbored bacteriophages, and there was strong evidence that some of the bacteriophages were different from the previously characterized ΦAaPhage.actinomyceremcomitansthe F‐Fragment phage were more frequently associated with periodontal disease. Five strains, all serotyype b, 3 from LJP patients and 2 from healthy subjects, showed a 530‐bp deletion in the promotor regiion of the leukotoxin gene.