ADRENAL RESPONSIVENESS AND SOCIAL-STATUS IN INTACT AND OVARIECTOMIZED MACACA-FASCICULARIS
ADRENAL RESPONSIVENESS AND SOCIAL-STATUS IN INTACT AND OVARIECTOMIZED MACACA-FASCICULARIS
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DOI：
10.1002/ajp.1350110209
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发表时间：
1986-01-01
影响因子：
2.4
通讯作者：
MANUCK, SB
中科院分区：
文献类型：
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作者：
KAPLAN, JR;ADAMS, MR;MANUCK, SB
在成年雌性食蟹猴（Macaca fascicularis）中检查了血浆皮质醇（F）对地塞米松抑制后静脉输注促肾上腺皮质激素（ACTH）的反应，这些食蟹猴在由4至6只雌性和1只雄性组成的社会群体中生活了22个月。这些雌性动物中的一部分被切除卵巢（n = 21），而其余的是生殖完整的（n = 23）。所有动物的社会行为进行了监测与焦点抽样程序，并根据战斗结果确定的优势等级。此外，对完整雌性动物进行阴道拭子以确定月经开始，并在其周期的黄体期每三天取样测定血浆孕酮（P）。结果表明，次级动物对ACTH输注的血浆F反应大于优势动物（P <0.02）。然而，在基线测量的血浆F中，次级和显性没有差异。进一步发现，在基线和注射ACTH后，卵巢切除女性的血浆F浓度高于正常女性（P <0.01）。最后，在ACTH注射后15分钟和30分钟测量期间，所有动物的血浆F都有明显升高（P <0.01）。随后的分析数据显示，从完整的女性之间的相互关系的优势排名，生殖功能（黄体期血浆P浓度），肾上腺大小，肾上腺皮质激素输注反应。这些数据表明，下属女性处于生殖劣势相比，占主导地位，这可能是介导的结果，在一定程度上，由肾上腺的大小和增强肾上腺反应的下属女性。
Plasma cortisol (F) response to intravenous adrenocortotropin (ACTH) infusion following dexamethasone suppression) was examined in adult female Macaca fascicularis that had been living for 22 months in social groups consisting of four to six females and one male. A portion of these females were ovariectomized (n = 21), while the rest were reproductively intact (n = 23). The social behavior of all animals was monitored with a focal sampling procedure, and dominance ranks were determined on the basis of fight outcomes. Further, intact females were swabbed vaginally to determine onset of menstruation and were sampled for plasma progesterone (P) every three days during the luteal phase of their cycles. Among the results was that the plasma F response to ACTH infusion was greater in subordinate animals than in dominants (P < .02). Subordinates and dominants did not, however, differ in plasma F measured at baseline. It was found further that plasma F concentrations were greater in ovariectomized than in intact females at baseline and following ACTH injection (P < .01). Finally, there was an appreciable elevation in plasma F across all animals during the 15- and 30-minute post-ACTH injection measurements (P < .01). Subsequent analyses of data from intact females showed interrelationships among dominance rank, reproductive function (indicated by luteal phase plasma P concentrations), adrenal size, and adrenal response to ACTH infusion. These data indicated that subordinate females were at a reproductive disadvantage compared to dominants, a result that may have been mediated, in part, by the increased adrenal size and enhanced adrenal responsiveness of subordinate females.